Oregon vs Oklahoma State Prediction Football Picks Today 9/12/26
Oregon Ducks (1-0) vs. Oklahoma State Cowboys (0-1)
September 12, 2026 12:00 pm EDT
The Line: Oklahoma State Cowboys 1100 / Oregon Ducks -2100; Over/Under: 55.5
(Get latest betting odds)
In this article, we will formulate an Oregon vs Oklahoma State Prediction for this College Football Week 2 matchup on Saturday, September 12th. Let’s take a look at the prediction for this College Football matchup.
Oklahoma State Cowboys Preview
The Oklahoma State Cowboys have a 0-1 record and are coming off a 10-24 road loss to Tulsa, where they were outgained 368-361 yards. Oklahoma State had 241 passing yards, 127 rushing yards, and 29/49 completed passes. They were 5/16 on third down conversions, had 6-59 penalties, and lost the turnover battle by 4-1.
Drew Mestemaker led Oklahoma State with 29/49 passes and 241 passing yards. Caleb Hawkins had a team-high 79 rushing yards, while Wyatt Young caught 8 passes for a team-high 84 receiving yards. Defensively, Ethan Wesloski led the Cowboys with 7 total tackles, 3 of them solo.
Oregon Ducks Preview
The Oregon Ducks have a 1-0 record and are coming off a 34-27 home win over Boise State, where they outgained them 497-274 yards. Oregon had 378 passing yards, 119 rushing yards, and 28/38 completed passes. They were 4/12 on third down conversions, had 10-90 penalties, and lost the turnover battle by 1-0.
Dante Moore led Oregon with 28/37 passes and 378 passing yards. Jordon Davison had a team-high 90 rushing yards, while Jeremiah McClellan caught 6 passes for a team-high 150 receiving yards. Defensively, Koi Perich led the Ducks with 11 total tackles, 3 of them solo, and Bear Alexander led the team with one sack.
Oregon Ducks @ Oklahoma State Cowboys Betting Trends: Week 2
Why the Oklahoma State Cowboys will win
- Oklahoma State has won each of its last 11 home openers.
- The underdog has covered the spread in each of Oklahoma State’s last five games.
- Oregon has failed to cover the spread in three of its last four games.
- Oklahoma State has won the first half in three of its last four September home games against AP-ranked teams.
- The underdog has won the first quarter in four of Oklahoma State’s last five games.
Why the Oregon Ducks will win
- Oregon has won each of its last 41 games against non-AP-ranked teams.
- Oklahoma State has lost each of its last 12 games.
- Oklahoma State has failed to cover the spread in seven of its last eight games against AP-ranked teams.
- Oregon has covered the spread in five of its last six road openers as a favorite.
- Oregon has won the first quarter in seven of its last eight road games against non-AP-ranked teams.
- Oklahoma State has lost the first half in each of its last eight games as a home underdog.
Total Points Facts
- Each of Oklahoma State’s last four games have gone UNDER the total points line.
- Four of Oregon’s last five games as a favorite have gone OVER the total points line.
Oklahoma State Cowboys Player Prop Facts
- Heading into Week 2, Wyatt Young ranks T21st amongst FBS players for receptions (8) this season.
Oregon Ducks Player Prop Facts
- Dante Moore has recorded a 130.0+ passer rating in seven consecutive games – equal-longest streak in the FBS.
Matchup/League Facts
- Oklahoma State ranks T122nd among FBS teams for points per game this season (10.0).
- Oklahoma State is one of 17 FBS teams to score 10 points or less in every game this season.
- One of Oregon’s one games this season have been decided by a margin of seven points or less – equal-most amongst FBS teams.
- Oregon ranks T1st among FBS teams for red zone percentage this season (100.0).
Oregon vs Oklahoma State Prediction
In this Oregon vs Oklahoma State Prediction, Oregon is coming as -23.5 road favorites. Both teams are coming off opposite outcomes in their opening games of the season and Oklahoma State continued where they left off last season’s horrible 1-11 season (5-7 ATS), as they lost by scoring just 10 points. They will have to host the #4 projected team in the country this season in Oregon, who were undefeated on the road last season and were 9-6 against the spread. The difference here is huge and I will gladly lay the -23.5 points with Oregon on the road in this one.