Penn State vs Indiana Prediction Football Picks Today 11/8/25

In this article we will formulate a Penn State vs Indiana prediction for this College Football game on Saturday, November 8th at Beaver Stadium in University Park, Pennsylvania. Let’s take a look at the prediction for this week 11 matchup. 

Penn State Nittany Lions Betting Preview

The Penn State Nittany Lions are 3-5 (0-5) this year after they lost to Ohio State by a score of 38-14 last week. Penn State trailed 17-14 at halftime, but they were out scored 21-0 in the second half for the lopsided loss. The Nittany Lions were out gained by a total of 480-200, went 8-15 on third downs, and tied the turnover battle at one in the game. Ethan Grunkemeyer went 19-28 for 145 yard and one interception, while Kaytron Allen rushed 21 times for 76 yards and one score. Nicholas Singleton led the receivers with three catches for 28 yards in the loss. The PSU defense recorded zero sacks and four tackles for loss in the game. 

Prior to that game, Penn State lost to Iowa by a score of 25-24 and Northwestern by a score of 22-21. The Nittany Lions have lost five games in a row and they are currently near the bottom of the Big Ten standings. Penn State has scored 30.8 points per game with 180.4 passing yards and 155.3 rushing yards per game, while they have allowed 21.8 points against per game this season. Ethan Grunkemeyer has thrown for 343 yards, one touchdown, and three interceptions, while Kaytron Allen has rushed 119 times for 688 yards and 10 scores this year. 

Indiana Hoosiers Betting Preview

The Indiana Hoosiers are 9-0 (6-0) this season after they defeated Maryland by a score of 55-10 in their last game. Indiana led 20-3 at halftime and scored 35 points in the second half for the easy victory. The Hoosiers out gained Maryland by a total of 588-293, went 8-13 on third downs, and won the turnover battle by a total of 5-1 in the game. Fernando Mendoza went 14-21 for 201 yards, one touchdown, and one interception, while Kaelon Black rushed 14 times for 110 yards and one score. Omar Cooper Jr led the receivers with seven receptions for 86 yards and one touchdown in the win. The Indiana defense recorded zero sacks and three tackles for loss in the game. 

Prior to that game, Indiana defeated UCLA by a score of 56-6 and Michigan State by a score of 38-13. The Hoosiers have won all nine games to start this year and they are currently first in the Big Ten standings. Indiana has scored 46.4 points per game with 259.2 passing yards and 245.7 rushing yards per game, while they have allowed 10.8 points against per game this season. Fernando Mendoza has thrown for 2,124 yards, 25 touchdowns, and four interceptions, while Omar Cooper Jr has 46 receptions for 669 yards and eight scores this season. 

Why the Penn State Nittany Lions will win

• Penn State has won nine of its last 10 games against Indiana.
• The underdog has covered the spread in eight of Penn State’s last nine games.
• The team ranked 2nd in the AP Poll has failed to cover the spread in six of its last eight games.
• Penn State has won the first half in 13 of its last 17 home games against conference opponents.

Total Points Facts

• Each of Indiana’s last eight road games in November have gone OVER the total points line.
• Eight of Penn State’s last nine games against conference opponents have gone OVER the total points line.

Matchup/League Facts

• Penn State ranks T7th among FBS teams for Q4 points per game this season (10.3).
• Penn State ranks 14th among FBS teams for passing yards allowed per game this season (166.4).
• Indiana ranks 1st among FBS teams for points per game this season (46.4).
• Indiana has recorded the most home wins by a margin of 10+ points of any FBS team this season (6).

Penn State vs Indiana Prediction 

Penn State comes into this matchup looking for their first conference win of the season and they have allowed at least 30 points in three of their last five games, but they will be at home here. Indiana is undefeated through nine games and they are ranked #2 in the country, but will face a decent Penn State defense. The Nittany Lions have to control the line of scrimmage and time of possession if they want to stay in this game, and I think they can take some positives from last week’s first half against OSU. I think this Penn State rushing attack can do just enough to slow this game down and I like the Nittany Lions to cover here. 

David Racey is 104-85 (55%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!