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Penn State vs Michigan State Prediction 11/15/25 College Football Picks Today

Penn State vs Michigan State
November 15, 2025 3:30 pm EDT
The Line: Penn State -7 / Over/Under: 48.5
(Get latest betting odds)

In this article, we will formulate a Notre Dame vs Pitt Prediction for this College Football Week 12 game on Saturday, November 15th. Let’s take a look at the prediction for this College Football matchup.

Michigan State Spartans Preview

Michigan State has a 3-6 record this season and is sitting 16th in the Big Ten. They are 5-4-0 ATS, 6-3-0 in Over/Under and have a 3-2 home record and a 0-4 away record. Michigan State is coming off a 20-23 road loss against Minnesota and will face Penn State, Iowa and Maryland next.

Offensively, Michigan State averages 25.6 points per game, ranking 82nd in the nation, while defensively, they allow 31.4 points per game, which is 116th. Michigan State averages 347.7 total yards per game (221.9 passing and 125.8 rushing), while allowing 371.3 total yards per game (144.3 rushing and 227.0 passing).

Aidan Chiles leads Michigan State with 1,392 passing yards with 63.1% completed passes and 10 touchdowns. Makhi Frazier leads the team in rushing yards with 493, while Nick Marsh has a team-high 46 receptions for 554 receiving yards. Defensively, Jordan Hall has a team-high 70 total tackles (38 of them solo), while Malik Spencer leads the team in sacks, with 2.

Penn State Nittany Lions Preview

Penn State has a 3-6 record this season and is sitting 17th in the Big Ten. They are 2-7-0 ATS, 6-2-1 in Over/Under and have a 3-3 home record and a 0-3 away record. Penn State is coming off a 24-27 home loss against Indiana and will face Nebraska and Rutgers next.

Offensively, Penn State averages 30.7 points per game, ranking 52nd in the nation, while defensively, they allow 22.3 points per game, which is 52nd. Penn State averages 335.7 total yards per game (184.7 passing and 151.0 rushing), while allowing 325.8 total yards per game (153.7 rushing and 172.1 passing).

Drew Allar leads Penn State with 1,100 passing yards with 64.8% completed passes and 8 touchdowns. Kaytron Allen leads the team in rushing yards with 736, while Trebor Pena has a team-high 32 receptions for 331 receiving yards. Defensively, Amare Campbell has a team-high 67 total tackles (41 of them solo), while Dani Dennis-Sutton leads the team in sacks, with 3.

Penn State Nittany Lions @ Michigan State Spartans Betting Trends: Week 12

 

Why the Michigan State Spartans will win

  • Penn State has lost each of its last seven games against conference opponents.
  • Michigan State has won 13 of its last 16 November home games against non-AP-ranked teams.
  • The underdog has covered the spread in each of Michigan State’s last 11 games.
  • Penn State has failed to cover the spread in each of its last seven games as a favorite.

Why the Penn State Nittany Lions will win

  • Penn State has won each of its last 14 November games against non-AP-ranked teams.
  • Michigan State has lost each of its last seven games against conference opponents.
  • Michigan State has failed to cover the spread in each of its last six home games against non-AP-ranked teams.
  • Penn State has covered the spread in four of its last five games against Michigan State.
  • Michigan State has lost the first half in each of its last seven games against conference opponents.

Total Points Facts

  • Eight of Michigan State’s last nine games as an underdog have gone OVER the total points line.
  • Each of Penn State’s last four road games against non-AP-ranked teams have gone OVER the total points line.

Michigan State Spartans Player Prop Facts

  • Heading into Week 12, Ryan Eckley ranks 1st amongst qualified players for gross average yards per punt (49.7) this season.

Penn State Nittany Lions Player Prop Facts

  • Heading into Week 12, Kaytron Allen ranks T17th amongst FBS players for rushing touchdowns (10) this season.

Matchup/League Facts

  • Michigan State has lost the first quarter in each of its last six games – longest active streak in the FBS.
  • Michigan State ranks T123rd among FBS teams for interceptions this season (3).
  • Penn State ranks 3rd among FBS teams for Q4 points per game this season (10.7).
  • Penn State ranks 15th among FBS teams for passing yards allowed per game this season (172.1).

Penn State vs Michigan State Prediction

In this Penn State vs Michigan State Prediction, Penn State is coming as -7-point road favorites, with the total set at 48.5 points. Both teams have identical overall records and both have been in terrible form lately, with six consecutive losses each. They both have been playing some higher-scoring games lately, as they are 11-3 to the over in their last 14 games combined. Take the over 48.5 points in this one.

Nikos Lagouretos's Free Pick: Over 48.5

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