Purdue vs Indiana Prediction Football Picks Today 11/28/25

In this article we will formulate a Purdue vs Indiana prediction for this College Football game on Friday, November 28th at Ross-Ade Stadium in West Lafayette, Indiana. Let’s take a look at the prediction for this week 14 matchup. 

Purdue Boilermakers Betting Preview

The Purdue Boilermakers are 2-9 (0-8) this season after they lost to Washington by a score of 49-13 in their last game. Purdue trailed 28-0 at halftime and they allowed 21 points in the second half, but they did score 13 points after halftime to avoid the shutout. The Boilermakers were out gained by a total of 506-267, went 5-14 on third downs, and tied the turnover battle at one in the game. Malachi Singleton went 16-28 for 150 yards and one touchdown, while EJ Horton Jr rushed for 31 yards on just one carry. Nitro Tuggle led the receivers with three receptions for 57 yards in the loss. 

Prior to that game, Purdue lost to Ohio State by a score of 34-10 and Michigan by a score of 21-16. The Boilermakers have lost nine games in a row and they are currently tied for last in the Big Ten standings. Purdue has scored 20.2 points per game with 215.3 passing yards and 133.9 rushing yards per game, while they have allowed 29.6 points against per game this season. Ryan Browne has thrown for 1,915 yards, nine touchdowns, and nine interceptions, while Nitro Tuggle has 29 catches for 420 yards and four scores this season. 

Indiana Hoosiers Betting Preview

The Indiana Hoosiers are 11-0 (8-0) this year after they defeated Wisconsin by a score of 31-7 in their last game. Indiana was tied at seven in the second quarter, but they scored the last 21 points in the game to seal the win. The Hoosiers out gained Wisconsin by a total of 388-168, went 7-12 on third downs, and won the turnover battle by a total of 2-0 in the game. Fernando Mendoza went 22-24 for 299 yards and four touchdowns, while Roman Hemby rushed 14 times for 58 yards. Charlie Becker led the receivers with five catches for 108 yards and one score in the win. 

Prior to that game, Indiana defeated Penn State by a score of 27-24 and Maryland by a score of 55-10. The Hoosiers have won all 11 games this year and they are currently first in the Big Ten standings. Indiana has scored 43.3 points per game with 259.6 passing yards and 218.4 rushing yards per game, while they have allowed 11.6 points against per game this season. Fernando Mendoza has thrown for 2,641 yards, 30 touchdowns, and five interceptions, while Roman Hemby has rushed for 714 yards and five scores on 151 carries this year. 

Why the Indiana Hoosiers will win

• Indiana has won each of its last 20 games against non-AP-ranked teams.
• Purdue has lost each of its last 17 games against conference opponents.
• Purdue has failed to cover the spread in each of its last four games as an underdog against teams from Indiana.
• Indiana has covered the spread in five of its last six November road games against non-AP-ranked teams.
• Indiana has won the first half in each of its last six games against conference opponents.
• Indiana has won the first quarter in each of its last 11 games against conference opponents.

Total Points Facts

• Eight of Indiana’s last nine road games in November have gone OVER the total points line.
• Each of Purdue’s last four games as a home underdog against teams from Indiana have gone OVER the total points line.

Matchup/League Facts

• Purdue ranks 136th among FBS teams for Q2 opponent points per game this season (13.1).
• Purdue ranks 135th among FBS teams for average point differential in second quarters this season (-7.6).
• Indiana has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (7).
• Indiana has recorded the equal-most home wins by a margin of 35+ points of any FBS team this season (4).

Purdue vs Indiana Prediction 

Indiana comes into this matchup trying to complete a perfect regular season and they are huge favorites in this one. The Hoosiers have played very well for most of this year, but they have slowed down in their last two games against Penn State and Wisconsin. Purdue is looking for their first Big Ten win of the year and they have been outscored 83-23 in their last two games against Washington and Ohio State. The Boilermakers don’t have the offense to threaten Indiana in this game and the Hoosiers will be looking to make another statement. Take Indiana to cover here. 

David Racey is 140-118 (54%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!