Purdue vs Northwestern Prediction 10/18/25 College Football Picks Today

In this article, we will formulate a Purdue vs Northwestern Prediction for this College Football Week 8 game on Saturday, October 18^th at the Northwestern Medicine Field at Martin Stadium. Let’s take a look at the prediction for this College Football matchup.

Northwestern Wildcats Preview

Northwestern has a 4-2-0 record this season and is sitting 6th in the Big Ten. They are 4-2-0 ATS, 1-5-0 in Over/Under and have a 3-1-0 home record and a 1-1-0 away record. Northwestern is coming off a 22-21 road win against Penn State and will face Nebraska, USC and Michigan next.

Offensively, Northwestern averages 23.3 points per game, ranking 99th in the nation, while defensively, they allow 17.7 points per game, which is 24th. Northwestern averages 364.5 total yards per game (181.3 passing and 183.2 rushing), while allowing 305.3 total yards per game (145.0 rushing and 160.3 passing).

Preston Stone leads Northwestern with 1,081 passing yards with 62.1% completed passes and 8 touchdowns. Caleb Komolafe leads the team in rushing yards with 416, while Griffin Wilde has a team-high 32 receptions for 469 receiving yards. Defensively, Robert Fitzgerald has a team-high 47 total tackles (31 of them solo), while Anto Saka leads the team in sacks, with 2.0, and Mac Uihlein has a team-high two interceptions.

Purdue Boilermakers Preview

Purdue has a 2-4-0 record this season and is sitting 14th in the Big Ten. They are 2-3-1 ATS, 2-4-0 in Over/Under and have a 2-2-0 home record and a 0-2-0 away record. Purdue is coming off a 20-27 road loss against Minnesota and will face Rutgers, Michigan and Ohio State next.

Offensively, Purdue averages 26.5 points per game, ranking 80th in the nation, while defensively, they allow 29.3 points per game, which is 105th. Purdue averages 408.7 total yards per game (270.5 passing and 138.2 rushing), while allowing 375 total yards per game (129.3 rushing and 245.7 passing).

Ryan Browne leads Purdue with 1,541 passing yards with 60.4% completed passes and 7 touchdowns. Devin Mockobee leads the team in rushing yards with 402, while Michael Jackson III has a team-high 36 receptions for 354 receiving yards. Defensively, Charles Correa has a team-high 55 total tackles (21 of them solo), while CJ Nunnally IV leads the team in sacks, with 4.0, and Myles Slusher has a team-high one interception.

Purdue Boilermakers @ Northwestern Wildcats Betting Trends: Week 8

Why the Northwestern Wildcats will win

• Purdue has lost each of its last 12 road games.
• The favorite has won each of Purdue’s last 10 games.
• Purdue has failed to cover the spread in each of its last six October games against non-AP-ranked teams.
• Northwestern has covered the spread in four of its last five games.
• Northwestern has won the first quarter in three of its last four games against conference opponents.
• Purdue has lost the first half in 10 of its last 11 games against conference opponents.

Why the Purdue Boilermakers will win

• Northwestern has lost five of its last six home games against conference opponents.
• Purdue has covered the spread in 16 of its last 21 October games as a road underdog.
• Northwestern has lost the first half in five of its last six games against conference opponents.

Total Points Facts

• Each of Purdue’s last five games against non-AP-ranked teams have gone UNDER the total points line.
• Six of Northwestern’s last seven games as a home favorite against teams from Indiana have gone UNDER the total points line.

Northwestern Wildcats Player Prop Facts

• Heading into Week 8, Caleb Komolafe leads Northwestern for touchdowns (5) this season.

Purdue Boilermakers Player Prop Facts

• Heading into Week 8, Ryan Browne leads Purdue for touchdowns (5) this season.

Matchup/League Facts

• Northwestern has recorded the equal-most home wins by a margin of three points or less of any FBS team this season (1).
• Northwestern ranks 8th among FBS teams for time of possession per game this season (33:17).
• Purdue ranks T132nd among FBS teams for Q2 opponent points per game this season (12.5).
• Purdue ranks T128th among FBS teams for interceptions this season (1).

Purdue vs Northwestern Prediction

In their previous meeting last season, Northwestern won 26-20 in overtime on the road. They are 7-3 in their last 10 meetings against Purdue, but Purdue is 2-1 in their last 3 visits in Northwestern. Under is 4-1 in their last 5 meetings.

In this Purdue vs Northwestern Prediction, Northwestern is coming as -3-point home favorites, with the total set at 46.5 points. Both teams have been in completely opposite trajectories lately, with the Wildcats having three straight wins, and a strong 3-1 home record. On the flip side, the Boilermakers have four consecutive losses, having lost both road games this season. The value here lies with the home favorite, so take Northwestern and lay the -3 points in this one,