College Football

Southern Miss vs Tulane Prediction Football Picks Today 9/26/26

Southern Mississippi Golden Eagles (1-2) vs. Tulane Green Wave (1-2)
September 26, 2026 7:00 pm EDT
The Line: Tulane Green Wave -1050 / Southern Mississippi Golden Eagles 675; Over/Under: 52.5
(Get latest betting odds)

In this article, we will formulate a Southern Miss vs Tulane Prediction for this College Football Week 4 matchup on Saturday, September 26th. Let’s take a look at the prediction for this College Football matchup.

Tulane Green Wave Preview

Tulane has a 1-2 record and are coming off a 20-31 road loss against Kansas State. They will face Army and Memphis next. Offensively, Tulane averages 17 points per game, ranking 128th in the nation, while defensively, they allow 24 points per game, which is 84th. Tulane averages 314 total yards per game (193.7 passing and 120.3 rushing), while allowing 429 total yards per game (211 rushing and 218 passing).

Kadin Semonza leads Tulane with 517 passing yards with 55.1% completed passes and 2 touchdowns. Jaylin Lucas leads the team in rushing yards with 215, while Destyn Hill has a team-high 9 receptions for 158 receiving yards. Defensively, Kevin Adams III has a team-high 29 total tackles (21 of them solo), while Makai Williams leads the team with one sack.

Southern Miss Golden Eagles Preview

Southern Miss has a 1-2 record and are coming off a 20-48 home loss against UConn. They will face Troy and Arkansas State next. Offensively, Southern Miss averages 25.7 points per game, ranking 96th in the nation, while defensively, they allow 31.3 points per game, which is 118th. Southern Miss averages 388.3 total yards per game (232 passing and 156.3 rushing), while allowing 424 total yards per game (220 rushing and 204 passing).

Ethan Hampton leads Southern Miss with 419 passing yards with 60% completed passes and 2 touchdowns. Steven Robinson leads the team in rushing yards with 246, while Mario Sanders II has a team-high 16 receptions for 233 receiving yards. Defensively, Mathias Haygood has a team-high 23 total tackles (6 of them solo), while Jyaire Brown leads the team with one sack.

Southern Miss Golden Eagles @ Tulane Green Wave Betting Trends: Week 4

 

Why the Tulane Green Wave will win

  • Tulane has won 20 of its last 21 games against non-AP-ranked teams at Yulman Stadium.
  • Southern Miss has lost each of its last nine games as a road underdog.
  • Southern Miss has failed to cover the spread in eight of its last nine September games as an underdog.
  • Tulane has covered the spread in four of its last five home games against non-conference opponents.
  • Southern Miss has lost the first half in each of its last 11 road games against non-conference opponents.
  • Tulane has won the first quarter in eight of its last nine September home games against non-AP-ranked teams.

Why the Southern Miss Golden Eagles will win

  • Tulane has lost four of its last five games against non-conference opponents.
  • The road team has won each of the last three games between Southern Miss and Tulane.
  • Tulane has failed to cover the spread in each of its last five games as a home favorite.
  • The underdog has covered the spread in each of Tulane’s last five games at Yulman Stadium.
  • Tulane has lost the first half in four of its last five games against non-conference opponents.

Total Points Facts

  • Each of Tulane’s last four games against teams from Mississippi have gone UNDER the total points line.
  • Five of Southern Miss’ last six games as an underdog in Louisiana have gone OVER the total points line.

Tulane Green Wave Player Prop Facts

  • Heading into Week 4, Tavare Smith ranks 4th in the American Conference for kick return yards (92) this season.

Southern Miss Golden Eagles Player Prop Facts

  • Heading into Week 4, Ja’Kobi Albert ranks T2nd amongst FBS players for interceptions (3) this season.

Matchup/League Facts

  • Tulane ranks 138th among FBS teams for time of possession per game this season (24:01).
  • Tulane ranks T1st among FBS teams for red zone percentage this season (100.0).
  • Southern Miss ranks T132nd among FBS teams for Q1 opponent points per game this season (11.3).
  • Southern Miss ranks 131st among FBS teams for rushing yards allowed per game this season (220.0).

Southern Miss vs Tulane Prediction

In this Southern Miss vs Tulane Prediction, Tulane is coming as -18.5 home favorites. Both teams have identical records this season and are both coming off defeats in the previous week. They both are 1-2 against the spread and Southern Miss has been better offensively and has a -5.6 point differential, while Tulane has a better defense and a -7 point differential, so those two teams are very close in paper, which does not justify a -18.5 spread in favor of the hosts. I expect the guests to keep this one close, so take Southern Miss and grab those +18.5 points in this one.

 

Nikos Lagouretos's Free Pick: Southern Mississippi +18.5

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