Syracuse vs SMU Prediction 10/4/25 College Football Picks Today

In this article, we will formulate a Syracuse vs SMU Prediction for this College Football Week 6 game on Saturday, October 4^th at the Gerald J. Ford Stadium. Let’s take a look at the prediction for this College Football matchup.

SMU Preview

SMU has a 2-2 record this season and is sitting on the 12^th place of the Atlantic Coast. They are 0-4 ATS, 1-3 in Over/Under and have a 1-1 away record and 1-1 home record. The Mustangs are coming off a 24-35 road loss at Texas Christian and are playing Stanford and Clemson next.

Offensively, the Mustangs average 34.8 points per game, which ranks 46th in the nation. Defensively, they allow 26.5 points per game, which is 90th. SMU averages 422.5 total yards per game, with 141.0 rushing yards and 281.5 passing yards per game. They allow 449.3 total yards per game, with 114.8 rushing and 334.5 passing yards per game.

Kevin Jennings leads the Mustangs with 1126 passing yards and 68.3% completed passes. TJ Harden leads the team in rushing yards, with 309, while TJ Harden has a team-high 19 caught passes for 365 receiving yards, and has 3 touchdowns. Defensively, Isaiah Nwokobia has a team-high 31 total tackles, 17 of them solo. Cam Robertson leads the Mustangs in sacks, with 3, while Isaiah Nwokobia has one interception.

Syracuse Preview

Syracuse has a 3-2 record this season and is sitting on the 7^th place of the Atlantic Coast. They are 2-2-1 ATS, 3-2 in Over/Under and have a 1-0 away record and 2-1 home record. The Orange are coming off a 3-38 home loss vs Duke and are playing Pitt and Georgia Tech next.

Offensively, the Orange average 31.2 points per game, which ranks 64th in the nation. Defensively, they allow 29.6 points per game, which is 112th. Syracuse averages 441.0 total yards per game, with 112.0 rushing yards and 329.0 passing yards per game. They allow 464.6 total yards per game, with 174.0 rushing and 290.6 passing yards per game.

Steve Angeli leads the Orange with 1317 passing yards and 62.8% completed passes. Yasin Willis leads the team in rushing yards, with 296, while Johntay Cook II has a team-high 24 caught passes for 308 receiving yards, and has 1 touchdown. Defensively, Gary Bryant III has a team-high 27 total tackles, 11 of them solo. Braheem Long Jr. leads the Orange in sacks, with 2, while Darian Chestnut has two interceptions.

Syracuse Orange @ SMU Mustangs Betting Trends: Week 6

Why the SMU Mustangs will win

• SMU has won each of its last 10 games against conference opponents at Gerald J. Ford Stadium.
• Syracuse has lost 16 of its last 20 road games in October.
• SMU has covered the spread in seven of its last eight games in October.
• Syracuse has failed to cover the spread in five of its last six October games as an underdog.
• SMU has won the first quarter in seven of its last eight games against conference opponents at Gerald J. Ford Stadium.
• SMU has won the first half in 17 of its last 18 games against conference opponents.

Why the Syracuse Orange will win

• Syracuse has won six of its last seven games against non-AP-ranked teams.
• SMU has failed to cover the spread in each of its last six games.
• Syracuse has covered the spread in six of its last eight October games against non-AP-ranked teams.

Total Points Facts

• Six of SMU’s last seven October home games against non-AP-ranked teams have gone OVER the total points line.
• Four of Syracuse’s last five October games as an underdog against non-AP-ranked teams have gone OVER the total points line.

SMU Mustangs Player Prop Facts

• Kevin Jennings has recorded 275+ passing yards in three consecutive games – equal-longest streak in the FBS, heading into Week 6.

Syracuse Orange Player Prop Facts

• Heading into Week 6, Justus Ross-Simmons leads the Atlantic Coast Conference for receiving touchdowns (5) this season.

Matchup/League Facts

• SMU ranks 136th among FBS teams for passing yards allowed per game this season (334.5).
• SMU has had a lower time of possession than its opponents in each of its last 13 games – longest active streak in the FBS.
• Syracuse ranks T134th among FBS teams for 1st downs against this season (119).
• Syracuse ranks 132nd among FBS teams for passing yards allowed per game this season (290.6).

Syracuse vs SMU Prediction

In this Syracuse vs SMU Prediction, SMU is coming as -17-point home favorites, with the total set at 58.5 points. The Mustangs have both a better offense and defense than the Orange, but they have less wins this season and are just 1-1 at home, and have failed to cover all of their four games played. On the flip side, Syracuse is 3-1 in their last four games, and have won and covered their only game on the road, so I like them to keep this one relatively close. Take Syracuse and the +17 points in this one.