Syracuse vs UConn Prediction Football Picks Today 9/6/25
UConn Huskies (1-0) vs. Syracuse Orange (0-1)
September 6, 2025 12:00 pm EDT
The Line: Syracuse Orange -6.5 / UConn Huskies 6.5; Over/Under: 58.5
(Get latest betting odds)
The UConn Huskies and Syracuse Orange meet Saturday in college football action at JMA Wireless Dome. Here’s a Syracuse vs UConn Prediction. This article will include a Syracuse vs UConn Pick.
UConn Huskies Betting Preview
The UConn Huskies beat Central Connecticut, and they play Delaware and Ball State next. The UConn Huskies haven’t started a season 2-0 since 2015. Joe Fagnano is completing 72 percent of his passes for 260 yards, 3 touchdowns, and 0 interceptions. Skyler Bell and Chris Parker have combined for 194 receiving yards and 2 touchdowns, while Jackson Harper has 5 receptions.
The UConn Huskies ground game is averaging 250 yards per contest, and Cam Edwards leads the way with 115 yards and 1 touchdown. Defensively, UConn is allowing 13 points and 257 yards per game. Tyquan King leads the UConn Huskies with 8 tackles, Bryun Parham has 1 sack and Cam Chadwick has 1 pass deflection.
Syracuse Orange Betting Preview
The Syracuse Orange lost to Tennessee and plays Colgate and Clemson next. Syracuse hasn’t started a season 0-2 since 2020. Steve Angeli is completing 57.5 percent of his passes for 274 yards, 1 touchdown and 1 interception. Johnny Cook and Dan Villari have combined for 113 receiving yards and 1 touchdown, while Justus Ross-Simmons has 3 receptions.
The Syracuse Orange ground game is averaging 103 yards per contest, and Yasin Willis leads the way with 91 yards and 3 touchdowns. Defensively, Syracuse is allowing 45 points and 495 yards per game. David Reese leads the Syracuse Orange with 7 tackles, Chris Peal has 1 pass deflection and Anwar Sparrow has 1 pass deflection.
Why the Syracuse Orange will win
- Connecticut has lost each of its last 17 road games in September.
- Syracuse has won each of its last six games against non-conference opponents at JMA Wireless Dome.
- Connecticut has failed to cover the spread in seven of its last eight road openers.
- Connecticut has lost the first half in 16 of its last 18 games against opponents from the Atlantic Coast Conference.
Why the Connecticut Huskies will win
- The underdog has won four of Syracuse’s last six games at JMA Wireless Dome.
- The underdog has covered the spread in each of Syracuse’s last seven games at JMA Wireless Dome.
- Syracuse has failed to cover the spread in seven of its last eight games against non-conference opponents.
Syracuse Orange Player Prop Facts
- Heading into Week 2, Yasin Willis ranks T2nd amongst FBS players for rushing touchdowns (3) this season.
Connecticut Huskies Player Prop Facts
- Joe Fagnano has thrown two or more touchdown passes in five consecutive games – equal-longest streak in the FBS.
Syracuse vs UConn Prediction
Syracuse is probably the more talented team, but this is a lot of points to give an experienced and improved UConn side. UConn can move the football offensively, has playmakers, and has covered four of its last six games as an underdog. Syracuse is 0-5-1 ATS in its last 6 games when favorites of 5 or more points. There should be some UConn fans in the building as well, as it’s not a long trip. It feels like UConn is being disrespected a bit with this thick line. Give me the points.