USC vs Notre Dame Prediction 10/18/25 College Football Picks Today

In this article, we will formulate a USC vs Notre Dame Prediction for this College Football Week 8 game on Saturday, October 18^th at the Notre Dame Stadium. Let’s take a look at the prediction for this College Football matchup.

Notre Dame Fighting Irish Preview

Notre Dame has a 4-2-0 record this season and are 3-2-1 ATS, 4-2-0 in Over/Under and have a 3-1-0 home record and a 1-1-0 away record. Notre Dame is coming off a 36-7 home win against North Carolina State and will face Boston College, Navy and Pitt next.

Offensively, Notre Dame averages 40 points per game, ranking 14th in the nation, while defensively, they allow 20.8 points per game, which is 47th. Notre Dame averages 465.5 total yards per game (292.8 passing and 172.7 rushing), while allowing 351.5 total yards per game (106.2 rushing and 245.3 passing).

CJ Carr leads Notre Dame with 1,622 passing yards with 66.5% completed passes and 13 touchdowns. Jeremiyah Love leads the team in rushing yards with 530, while Jordan Faison has a team-high 29 receptions for 376 receiving yards. Defensively, Drayk Bowen has a team-high 31 total tackles (9 of them solo), while Boubacar Traore leads the team in sacks, with 5.5, and Leonard Moore has a team-high 3 interceptions.

USC Trojans Preview

USC has a 5-1-0 record this season and is sitting 3rd in the Big Ten. They are 3-3-0 ATS, 4-2-0 in Over/Under and have a 4-0-0 home record and a 1-1-0 away record. USC is coming off a 31-13 home win against Michigan and will face Nebraska, Northwestern and Iowa next.

Offensively, USC averages 45.5 points per game, ranking 3rd in the nation, while defensively, they allow 21.3 points per game, which is 52nd. USC averages 552.3 total yards per game (325.8 passing and 226.5 rushing), while allowing 352.2 total yards per game (108.5 rushing and 243.7 passing).

Jayden Maiava leads USC with 1,852 passing yards with 71.9% completed passes and 13 touchdowns. Waymond Jordan leads the team in rushing yards with 576, while Makai Lemon has a team-high 44 receptions for 682 receiving yards. Defensively, Eric Gentry has a team-high 41 total tackles (35 of them solo), while Braylan Shelby leads the team in sacks, with 3.5, and Bishop Fitzgerald has a team-high 5 interceptions.

USC vs Notre Dame Prediction

In their previous meeting last season, Notre Dame won 49-35 on the road, and are 6-1 in their last 7 meetings against USC. They have won their last 5 home meetings against USC and over is 7-3 in their last 10 meetings.

In this USC vs Notre Dame Prediction, Notre Dame is coming as -9-point home favorites, with the total set at 61.5 points. Both teams have been red-hot lately, with Notre Dame having won four straight games after losing their first two of the season, and USC having lost only once in their six games. Looking at the total, both teams are 8-4 to the over combined this season, and they are both elite offensively, scoring 85.5 points per game combined. Last season they combined for a whopping 84 total points, and I expect another high-scoring affair today. Take the over 61.5 points in this one.