USC vs Oregon Prediction 11/22/25 College Football Picks Today

In this article, we will formulate a USC vs Oregon Prediction for this College Football Week 13 game on Saturday, November 22^nd. Let’s take a look at the prediction for this College Football matchup.

Oregon Ducks Preview

Oregon has a 9-1 record this season and is sitting 4th in the Big Ten. They are 5-4-1 ATS, 5-5-0 in Over/Under and have a 5-1 home record and a 4-0 away record. Oregon is coming off a 42-13 home win against Minnesota and will face Washington next.

Offensively, Oregon averages 39.0 points per game, ranking 7th in the nation, while defensively, they allow 13.7 points per game, which is 5th. Oregon averages 475.4 total yards per game (241.8 passing and 233.6 rushing), while allowing 235.4 total yards per game (108.1 rushing and 127.3 passing).

Dante Moore leads Oregon with 2,190 passing yards with 72.8% completed passes and 21 touchdowns. Noah Whittington leads the team in rushing yards with 623, while Kenyon Sadiq has a team-high 30 receptions for 407 receiving yards. Defensively, Bryce Boettcher has a team-high 81 total tackles (31 of them solo), while Teitum Tuioti leads the team in sacks, with 5.5, and Jerry Mixon has a team-high 2 interceptions.

USC Trojans Preview

USC has an 8-2 record this season and is sitting 3rd in the Big Ten. They are 5-5-0 ATS, 5-5-0 in Over/Under and have a 6-0 home record and a 2-2 away record. USC is coming off a 26-21 home win against Iowa and will face UCLA next.

Offensively, USC averages 38.2 points per game, ranking 10th in the nation, while defensively, they allow 21.7 points per game, which is 36th. USC averages 488.9 total yards per game (298.1 passing and 190.8 rushing), while allowing 344.1 total yards per game (145.8 rushing and 198.3 passing).

Jayden Maiava leads USC with 2,868 passing yards with 66.8% completed passes and 18 touchdowns. King Miller leads the team in rushing yards with 719, while Makai Lemon has a team-high 71 receptions for 1,090 receiving yards. Defensively, Eric Gentry has a team-high 64 total tackles (45 of them solo), while Kameryn Crawford leads the team in sacks, with 3.5, and Bishop Fitzgerald has a team-high 5 interceptions.

USC Trojans @ Oregon Ducks Betting Trends: Week 13

Oregon Ducks Player Prop Facts

• Heading into Week 13, Noah Whittington ranks 2nd amongst qualified players for Yards Per Carry (8.2) this season.

USC Trojans Player Prop Facts

• Heading into Week 13, Bishop Fitzgerald ranks T1st amongst FBS players for interceptions (5) this season.

Matchup/League Facts

• Oregon has recorded the largest margin of victory in a road game this season (46-points vs Rutgers on October 18, 2025).
• Oregon ranks 1st among FBS teams for passing yards allowed per game this season (127.3).
• USC ranks 3rd among FBS teams for red zone percentage against this season (67.7).
• USC ranks 6th among FBS teams for yards per game this season (488.9).

USC vs Oregon Prediction

In this USC vs Oregon Prediction, Oregon is coming as -9.5-point home favorites, with the total set at 60 points. Both teams have been excellent this season, with Oregon having lost only once in their 10 games played this season. Both offenses have been electrifying this season, ranking on the top-10 of the country and scoring a whopping 77.2 points per game combined. Take the over 60 in this one.