USC vs Oregon Prediction Football Picks Today 9/26/26

In this article we will formulate a USC vs Oregon prediction for this College Football game on Saturday, September 26th at the Los Angeles Memorial Coliseum in Los Angeles, California. Let’s take a look at the prediction for this Week 4 matchup. 

USC Trojans Betting Preview

The USC Trojans are 4-0 (1-0) this season after they defeated Rutgers by a score of 42-35 last week. USC led 20-14 at halftime and they won the second half 22-21, but the game was way closer than it should have been and they failed to cover. The Trojans out gained Rutgers by a total of 461-460, went 5-10 on third downs, and won the turnover battle by a total of 2-0 in the game. Jayden Maiava threw for 277 yards and two touchdowns, while Kayden Dixon-Wyatt caught five passes for 77 yards. King Miller rushed 16 times for 102 yards and one touchdown in the game. 

Prior to that win, USC defeated Louisiana by a score of 49-30 and Fresno State by a score of 39-0. The Trojans have scored 43.0 points per game with 324.8 passing yards and 175.5 rushing yards per game, while they have allowed 22.8 points against per game this season. Jayden Maiava has thrown for 1,173 yards with 12 touchdowns and one interception this season. 

Oregon Ducks Betting Preview

The Oregon Ducks are 2-1 (0-0) this year after they defeated Portland State by a score of 84-0 in their last game. Oregon led 49-0 at halftime and added 35 points in the second half for the blowout win. The Ducks out gained Portland State by a total of 726-103, went 11-14 on third downs, and won the turnover battle by a total of 2-0 in the game. Dante Moore threw for 280 yards and four touchdowns, while Evan Stewart caught three passes for 72 yards and one score. Jordon Davison rushed 13 times for 81 yards and two touchdowns in the win. 

Prior to that game, Oregon lost to Oklahoma State by a score of 39-31, but did defeat Boise State by a score of 34-27 before that. The Ducks have scored 49.7 points per game with 340.0 passing yards and 166.0 rushing yards per game, while they have allowed 22.0 points against per game this season. Dante Moore has thrown for 849 yards with nine touchdowns and zero interceptions this year. 

Why the USC Trojans will win

• USC has won each of its last 16 games as a top-15 AP-ranked team at Los Angeles Memorial Coliseum.
• USC has covered the spread in seven of its last eight September home games as a top-15 AP-ranked team.
• Oregon has failed to cover the spread in each of its last three September games as a road favorite.
• USC has won the first half in nine of its last 10 home games in September.
• USC has won the first quarter in each of its last six games.

Why the Oregon Ducks will win

• Oregon has won each of its last 10 games against teams from California.
• USC has lost nine of its last 10 games as an AP-ranked team against an AP-ranked team.
• USC has failed to cover the spread in seven of its last eight games.
• Oregon has covered the spread in five of its last six September games against AP-ranked teams.
• The favorite has won the first quarter in each of USC’s last seven games.
• Oregon has won the first half in each of its last nine games as a favorite against teams from California.

Total Points Facts

• Seven of USC’s last eight games against AP-ranked teams at Los Angeles Memorial Coliseum have gone OVER the total points line.
• Each of Oregon’s last four games have gone OVER the total points line.

USC Trojans Player Prop Facts

• Heading into Week 4, Jayden Maiava ranks 1st amongst FBS players for passing yards (1173) this season.

Oregon Ducks Player Prop Facts

• Heading into Week 4, Dylan Raiola has recorded the most completions without an unsuccessful attempt this season (11).

Matchup/League Facts

• USC has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (3).
• USC has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (3).
• Oregon ranks T1st among FBS teams for red zone percentage this season (100.0).
• Oregon has averaged 57.5 points over its last two games – most in the FBS over that span.

USC vs Oregon Prediction 

Oregon finally got back on track with an easy win over Portland State last week, but let’s see if they can continue that against a FBS opponent. The Ducks really struggled in their first two games and they allowed 66 points to Boise State and Oklahoma State. USC is undefeated, but they are 1-3 against the spread and nearly lost to Rutgers last week. I don’t like either defense in this game, so we should see plenty of scoring. Take the over here.