Charlotte 49ers (1-3) vs. South Florida Bulls (3-1)
October 3, 2025 7:00 pm EDT
The Line: South Florida Bulls -27 / Charlotte 49ers 27; Over/Under: 54.5
(Get latest betting odds)
The Charlotte 49ers and South Florida Bulls meet Friday in college football action at Raymond James Stadium. Here’s a USF vs Charlotte Prediction. This article will include a USF vs Charlotte Pick.
Charlotte 49ers Betting Preview
The Charlotte 49ers beat Monmouth, lost to Rice, and they play Army next. Charlotte has split its last 6 games. Conner Harrell is completing 66.7 percent of his passes for 737 yards, 4 touchdowns, and 2 interceptions. E. Jai Mason and Javen Nicholas have combined for 578 receiving yards and 4 touchdowns, while Miles Burris has 9 receptions.
The Charlotte 49ers ground game is averaging 88.3 yards per contest, and Rod Gainey Jr. leads the way with 145 yards and 1 touchdown. Defensively, Charlotte is allowing 29.3 points and 425 yards per game. Shay Taylor leads the Charlotte 49ers with 26 tackles, Reid Williford has 2 sacks and Dwight Bootle II has 1 pass deflection.
South Florida Bulls Betting Preview
The South Florida Bulls los tot Miami, beat South Carolina State, and play North Texas next. The South Florida Bulls have won 4 of their last 5 games. Byrum Brown is completing 62.9 percent of his passes for 983 yards, 6 touchdowns, and 2 interceptions. Chas Nimrod and Keshaun Singleton combined for 602 receiving yards and 4 touchdowns, while Alvon Isaac has 8 receptions.
The South Florida Bulls ground game is averaging 134.3 yards per contest, and Alvon Isaac leads the way with 121 yards on 21 carries. Defensively, South Florida is allowing 21.5 points and 403.5 yards per game. Mac Harris leads the South Florida Bulls with 36 tackles, Rico Watson III has 1 sack and James Chenault has 2 interceptions.
Charlotte 49ers @ South Florida Bulls Betting Trends: Week 6
South Florida Bulls Player Prop Facts
- Heading into Week 6, Chas Nimrod leads the American Conference for yards per reception (26.2) this season.
Charlotte 49ers Player Prop Facts
- Heading into Week 6, E. Jai Mason leads Charlotte for touchdowns (3) this season.
Matchup/League Facts
- South Florida ranks 136th among FBS teams for time of possession per game this season (22:35).
- South Florida ranks 2nd among FBS teams for Q3 points per game this season (14.5).
- Charlotte ranks T134th among FBS teams for red zone percentage this season (61.5).
- Charlotte ranks 131st among FBS teams for Q1 points per game this season (1.5).
USF vs Charlotte Prediction
Charlotte doesn’t do anything well on either side of the ball, is losing games, and isn’t covering numbers. Charlotte has failed to cover 4 of its last 5 games as a double-digit underdog. South Florida has played well through 4 games, is above-average offensively, has a bend but don’t break defense and has cashed 3 tickets.
USF has covered 4 of its last 5 games as a double-digit favorite. Thick line, but Charlotte is one of the worst teams in the country through the first quarter of the season. I’ll lay the points with USF in a comfortable home win.
