Ole Miss Rebels (3-1) vs. Vanderbilt Commodores (3-2)
October 10, 2026 3:30 pm EDT
The Line: Vanderbilt Commodores +9.5 / Ole Miss Rebels -9.5; Over/Under: 54.5
(Get latest betting odds)
The Ole Miss Rebels and the Vanderbilt Commodores meet in week 6 college football action from FirstBank Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Ole Miss Rebels vs. Vanderbilt Commodores Prediction.
Ole Miss Rebels Recap
The Ole Miss Rebels come into this game looking to rebound from a 52-28 loss at the hands of Florida last time out to sit at 3-1 this season. After this game, Ole Miss will head home for a game against Missouri.
Rebels Looking To Shake Off First Loss
Trinidad Chambliss has thrown for 1,222 yards, 8 touchdowns and 3 interceptions on 70.8% passing while Kewan Lacy leads Ole Miss in rushing with 191 yards and 4 touchdowns through 5 games this season. Trinidad Chambliss sits behind Lacy on the ground with 108 yards and 4 touchdowns. Deuce Alexander leads the Rebels in receiving with 429 yards and 27 catches along with 4 touchdowns, while Caleb Odom trails with 201 yards and 13 catches. On defense, Keaton Thomas has a team-high 29 tackles while Ole Miss’ defense as a whole has combined for 6 sacks and 2 interceptions through 5 games this season.
Vanderbilt Commodores Recap
The Vanderbilt Commodores come into this game looking to rebound from their 38-14 loss at the hands of Georgia last time out to sit at 3-2 this season. After this game, Vanderbilt will take on Arkansas in a matchup at home.
Commodores Drop Back-To-Back Games
Jared Curtis has thrown for 746 yards, 4 touchdowns and 3 interceptions on 64.3% passing while Sedrick Alexander leads Vanderbilt in rushing with 200 yards and 4 touchdowns through 5 games this season. Makhilyn Young sits behind Alexander on the ground with 134 yards and a touchdown. Junior Sherrill leads the Commodores in receiving with 474 yards and 28 catches along with 3 touchdowns, while Tristen Brown trails with 130 yards and 9 catches. On defense, CJ Heard has a team-high 38 tackles while Vanderbilt’s defense as a whole has combined for 14 sacks and 4 interceptions through 5 games this season.
Ole Miss Rebels @ Vanderbilt Commodores Betting Trends: Week 6
Why the Vanderbilt Commodores will win
- Vanderbilt has won each of its last 11 games in Tennessee.
- Ole Miss has lost six of its last eight October road games as a top-10 AP-ranked team.
- Vanderbilt has covered the spread in each of its last eight games against conference opponents.
- The team ranked 9th in the AP Poll has failed to cover the spread in each of its last four games.
- Vanderbilt has won the first quarter in three of its last four games against top-10 AP-ranked teams.
- The home team has won the first half in four of the last five games between Ole Miss and Vanderbilt.
Why the Ole Miss Rebels will win
- Ole Miss has won each of its last 12 games against non-AP-ranked teams.
- Vanderbilt has lost each of its last eight games as an underdog against teams from Mississippi.
- Ole Miss has covered the spread in eight of its last nine games as a favorite against teams from Tennessee.
- Vanderbilt has failed to cover the spread in each of its last three games as a home underdog against teams from Mississippi.
- Ole Miss has won the first half in 14 of its last 15 games as a favorite.
- Ole Miss has won the first quarter in 11 of its last 12 games against Vanderbilt.
Total Points Facts
- Each of Ole Miss’ last seven October games as a favorite have gone UNDER the total points line.
- Five of Vanderbilt’s last six games against conference opponents have gone OVER the total points line.
Vanderbilt Commodores Player Prop Facts
- Junior Sherrill has recorded 50+ receiving yards in 10 consecutive games – longest streak in the FBS, heading into Week 6.
Ole Miss Rebels Player Prop Facts
- Trinidad Chambliss has recorded a 130.0+ passer rating in 10 consecutive games – longest streak in the FBS.
Matchup/League Facts
- Vanderbilt has recorded the equal-most home wins by a margin of 10 points or less of any FBS team this season (2).
- Vanderbilt ranks 121st among FBS teams for Q2 points per game this season (4.8).
- Ole Miss ranks 138th among FBS teams for H2 opponent points per game this season (23.3).
- Ole Miss ranks T1st among FBS teams for red zone percentage this season (100.0).
Ole Miss Rebels vs. Vanderbilt Commodores Prediction
I’m leaning towards the under in this game. I just think that with this nasty weather that’s supposed to sweep through a lot of the south this weekend and affect a lot of games, I think this is one where the big advantage of Chambliss’ arm is negated and the focus is more on his legs and I don’t love the QB situation for Vanderbilt at all to begin with. Give me the under here.
