West Virginia vs Ohio Prediction 9/6/25 College Football Picks Today

In this article, we will formulate a West Virginia vs Ohio Prediction for this College Football Week 2 game on Saturday, September 6^th at the Peden Stadium. Let’s take a look at the prediction for this College Football matchup.

Ohio Bobcats Preview

The Bobcats are coming off a 31-34 road defeat in Rutgers in their season opener. Ohio outgained their opponents by 440-399 yards. They had 21/31 completed passes, 239 passing yards, 201 rushing yards, with both teams being 0-0 in turnovers. The Bobcats went 5-10 in third down efficiency and had 6-37 penalties.

Parker Navarro had 21/31 passes, a team-high 239 passing yards and three touchdowns. Sieh Bangura added a team-high 93 rushing yards and one touchdown, while Mason Williams caught 9 passes for 115 yards. Defensively, Torrie Cox Jr. had nine total tackles, six of them solo, while Cole Baker had one sack.

West Virginia Mountaineers Preview

The Mountaineers are coming off a 45-3 home victory over Robert Morris in their season opener. West Virginia outgained their opponents by 625-123 yards. They had 18/23 completed passes, 232 passing yards, 393 rushing yards, with turnovers being 4-2. The Mountaineers went 5-11 in third down efficiency and had 9-69 penalties.

Nicco Marchiol had 17/20 passes, a team-high 224 passing yards and one touchdown. Jahiem White added a team-high 93 rushing yards and two touchdowns, while Cam Vaughn caught 7 passes for 126 yards and one touchdown. Defensively, Trey Lathan had eight total tackles, six of them solo, while Tomiwa Durojaiye had one sack. Beanie Bishop had one interception for 27 yards.

West Virginia vs Ohio Prediction

This will be the first meeting between those two teams.

In this West Virginia vs Ohio Prediction, West Virginia is coming in as -3.5-point road favorites, with the total set at 60.5 points. Both teams are coming off opposite outcomes in their season openers, with West Virginia coming off a dominating 42-point win at home. Ohio is looking for their first win of the season and are now playing in front of their home crowd. The Bobcats were undefeated in their six home games last season, and were a strong 8-4 against the spread, while West Virginia was just 1-3 on the road and 5-7 against the spread. I like Ohio in this bounce-back spot, as home dogs, so take the Ohio Bobcats and the +3.5 points in your back pocket in this one.