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Western Kentucky vs Louisiana Tech Prediction 10/21/25 College Football Picks Today

Western Kentucky vs Louisiana Tech
October 21, 2025 7:30 pm EDT
The Line: Louisiana Tech -3.5 / Over/Under: 50
(Get latest betting odds)

In this article, we will formulate a Western Kentucky vs Louisiana Tech Prediction for this College Football Week 9 game on Tuesday, October 21st. Let’s take a look at the prediction for this College Football matchup.

Louisiana Tech Bulldogs Preview

Louisiana Tech has a 4-2 record this season and is sitting 4th in Conference USA. They are 5-1 ATS, 1-5 in Over/Under and have a 3-0 home record and a 1-2 away record. Louisiana Tech is coming off a 7-35 road loss against Kennesaw State and will face Sam Houston, Delaware and Washington State next.

Offensively, Louisiana Tech averages 24.5 points per game, ranking 91st in the nation, while defensively, they allow 17.2 points per game, which is 17th. Louisiana Tech averages 311 total yards per game (164.5 passing and 146.5 rushing), while allowing 355.3 total yards per game (106.3 rushing and 249 passing).

Blake Baker leads Louisiana Tech with 649 passing yards with 61.0% completed passes and 3 touchdowns. Clay Thevenin leads the team in rushing yards with 261, while Eli Finley has a team-high 17 receptions for 252 receiving yards. Defensively, Kolbe Fields and Jacob Fields are tied for the team-high with 39 total tackles, while Mekhi Mason leads the team in sacks, with 3.0, and Jakari Foster has a team-high 3 interceptions.

Western Kentucky Hilltoppers Preview

Western Kentucky has a 5-2 record this season and is sitting 3rd in Conference USA. They are 5-2 ATS, 3-4 in Over/Under and have a 3-1 home record and a 2-1 away record. Western Kentucky is coming off a 6-25 home loss against Florida International and will face Louisiana Tech, New Mexico State and Middle Tennessee State next.

Offensively, Western Kentucky averages 29.7 points per game, ranking 62nd in the nation, while defensively, they allow 23.1 points per game, which is 54th. Western Kentucky averages 416.9 total yards per game (294.6 passing and 122.3 rushing), while allowing 403.1 total yards per game (203.4 rushing and 199.7 passing).

Maverick McIvor leads Western Kentucky with 1,863 passing yards with 67.3% completed passes and 12 touchdowns. La’Vell Wright leads the team in rushing yards with 207, while Matthew Henry has a team-high 23 receptions for 435 receiving yards. Defensively, Jaylen Wester has a team-high 39 total tackles (19 of them solo), while Harper Holloman leads the team in sacks, with 2.0, and Jaylen Lewis has a team-high 2 interceptions.

Western Kentucky Hilltoppers @ Louisiana Tech Bulldogs Betting Trends: Week 9

 

Louisiana Tech Bulldogs Player Prop Facts

  • Heading into Week 9, Jakari Foster leads the Conference USA for interceptions (3) this season.

Western Kentucky Hilltoppers Player Prop Facts

  • Heading into Week 9, Cole Maynard ranks 2nd amongst qualified players for gross average yards per punt (49.9) this season.

Matchup/League Facts

  • Louisiana Tech ranks 1st among FBS teams for 4th down conversion percentage against this season (14.3).
  • Louisiana Tech ranks T4th among FBS teams for interceptions this season (11).
  • Western Kentucky ranks 3rd among FBS teams for Q4 opponent points per game this season (2.3).
  • Western Kentucky ranks T7th among FBS teams for average point differential in fourth quarters this season (+5.6).

Western Kentucky vs Louisiana Tech Prediction

In their previous meeting last season, Louisiana Tech won 12-7 on the road, and both teams are tied 4-4 in their 8 meetings, and 2-2 in their 4 meetings in Louisiana Tech. Under is 3-1 in their last 4 meetings.

In this Western Kentucky vs Louisiana Tech Prediction, Louisiana Tech is coming as -3.5-point home favorites, with the total set at 50 points. Both teams are coming off defeats that ended their previous winning streaks, and are both looking to bounce back. The Bulldogs have won and covered all of their three home games this season, and boast the 17th-best defense in the country and both teams have been playing lower-scoring games lately, as they are a perfect 7-0 to the under in their last 7 games combined, allowing 40.3 points per game combined this season. Last season they combined for just 19 points, and I expect another low-scoring affair today. Take the under 50 points in this one.

Nikos Lagouretos's Free Pick: Under 50

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