College Football

Nevada vs Wyoming Prediction Football Picks Today 11/22/25

Nevada Wolf Pack (2-8) vs. Wyoming Cowboys (4-6)
November 22, 2025 2:00 pm EDT
The Line: Wyoming Cowboys -250 / Nevada Wolf Pack 205; Over/Under: 40.5
(Get latest betting odds)

In this article, we will formulate a Nevada vs Wyoming Prediction for this College Football Week 13 game on Saturday, November 22nd. Let’s take a look at the prediction for this College Football matchup.

Wyoming Cowboys Preview

Wyoming has a 4-6 record this season and is sitting 9th in the MWC. They are 5-5 ATS, 2-8 in Over/Under and have a 3-2 home record and a 1-4 away record. Wyoming is coming off a 24-3 road loss against Fresno State and will face Hawaii next.

Offensively, Wyoming averages 17.8 points per game, ranking 128th in the nation, while defensively, they allow 20.6 points per game, which is 33rd. Wyoming averages 329.6 total yards per game (184.2 passing and 145.4 rushing), while allowing 344.3 total yards per game (168.4 rushing and 175.9 passing).

Kaden Anderson leads Wyoming with 1,791 passing yards with 56.2% completed passes and 11 touchdowns. Samuel Harris leads the team in rushing yards with 552, while Chris Durr has a team-high 39 receptions for 435 receiving yards. Defensively, Brayden Johnson has a team-high 63 total tackles (36 of them solo), while Ben Florentine leads the team in sacks, with 5, and Brayden Johnson, Desman Hearns have a team-high 2 interceptions each.

Nevada Wolf Pack Preview

Nevada has a 2-8 record this season and is sitting 12th in the MWC. They are 4-5-1 ATS, 4-6 in Over/Under and have a 2-3 home record and a 0-5 away record. Nevada is coming off a 55-10 home win against San Jose State and will face Nevada-Las Vegas next.

Offensively, Nevada averages 18.1 points per game, ranking 125th in the nation, while defensively, they allow 28.1 points per game, which is 92nd. Nevada averages 301.4 total yards per game (157.8 passing and 143.6 rushing), while allowing 372.2 total yards per game (150.1 rushing and 222.1 passing).

Carter Jones leads Nevada with 856 passing yards with 63.6% completed passes and 5 touchdowns. Caleb Ramseur leads the team in rushing yards with 500, while Jett Carpenter has a team-high 28 receptions for 306 receiving yards. Defensively, Dylan Labarbera has a team-high 76 total tackles (43 of them solo), while Dylan Labarbera leads the team in sacks, with 6.5, and Murvin Kenion III has a team-high 3 interceptions.

Nevada Wolf Pack @ Wyoming Cowboys Betting Trends: Week 13

 

Why the Wyoming Cowboys will win

  • Nevada has lost each of its last 10 road games.
  • The home team has won each of Wyoming’s last five games.
  • Wyoming has covered the spread in seven of its last eight home games in November.
  • Nevada has failed to cover the spread in four of its last five November games against non-AP-ranked teams.
  • Nevada has lost the first half in seven of its last eight games against conference opponents.

Why the Nevada Wolf Pack will win

  • Wyoming has lost four of its last five games in November.
  • Wyoming has failed to cover the spread in three of its last four November games against non-AP-ranked teams.

Total Points Facts

  • Each of Nevada’s last six November games as an underdog against non-AP-ranked teams have gone OVER the total points line.
  • Seven of Wyoming’s last eight games against conference opponents have gone UNDER the total points line.

Wyoming Cowboys Player Prop Facts

  • Heading into Week 13, Samuel Harris is one of only 17 players in the FBS to record 500 rushing yards with less than 100 attempts this season.

Nevada Wolf Pack Player Prop Facts

  • Heading into Week 13, Caleb Ramseur is one of only 11 players in the FBS to record 3+ rushing and 3+ receiving TDs this season.

Matchup/League Facts

  • Wyoming ranks 133rd among FBS teams for Q2 points per game this season (3.7).
  • Wyoming ranks 4th among FBS teams for red zone percentage against this season (69.0).
  • Nevada ranks 131st among FBS teams for red zone percentage this season (68.8).
  • Nevada ranks 130th among FBS teams for Q1 points per game this season (2.6).

Nevada vs Wyoming Prediction

In this Nevada vs Wyoming Prediction, Wyoming is coming as -6.5-point home favorites. Both teams are coming into this matchup in poor form, as Wyoming is 1-3 in its last 4 games and Nevada 1-7 in its last 8 and have been winless on the road this season. Both teams have been terrible offensively, as they score just 35.9 points per game combined, which is way lower than today’s total set at 40.5. Take the under in this one.

Nikos Lagouretos's Free Pick: Under 40.5

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