Draftkings NFL Showdown Picks: Chiefs vs. Giants 9/21/25
Kansas City Chiefs vs. New York Giants
September 21, 2025 8:20 pm EDT
The NFL presents Draftkings football fans with a regular season matchup featuring the Kansas City Chiefs and the New York Giants. Let’s take a look at this game from a DFS perspective.
Before we dive into the Kansas City Chiefs vs. New York Giants game let’s review the rules for the Draftkings single game showdown contest.
Draftkings Single Game Showdown Contest Rules
You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.
The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.
If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.
*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.
Here are my Draftkings picks for tonight’s Chiefs vs. Giants matchup.
Draftkings NFL Showdown Picks
Captain-Patrick Mahomes, Quarterback, Kansas City Chiefs $10,400
Unless you have been living under a rock the last decade, you are aware that Kansas City Chiefs quarterback Patrick Mahomes is a generational talent. With that said, how did the veteran signal caller perform from a statistical perspective in 2024? Let’s review Mahomes relevant key player game data from the 2024 NFL season to answer that question.
In the 16 games that quarterback Patrick Mahomes played for the Kansas City Chiefs in the 2024 NFL regular season, Mahomes amassed 3,928 passing yards, 26 passing touchdowns, 307 rushing yards and two rushing touchdowns.
Looking closer at the data just presented, in the 16 games that quarterback Patrick Mahomes played for the Kansas City Chiefs in 2024, Mahomes averaged a robust 19.6 Draftkings points a game.
In addition to the regular season, in three postseason games played in 2024, Mahomes compiled 679 passing yards, five passing touchdowns, 82 rushing yards and two rushing touchdowns.
Now that we have established how Mahomes played in 2024, let’s shift our focus to this season. In two games played in the 2025 NFL regular season, Mahomes has tallied 445 passing yards, two passing touchdowns, 123 rushing yards and two rushing touchdowns.
I also like Patrick Mahomes matchup in this game. Why? Upon the completion of two games played in the 2025 NFL regular season, in relation to the other 31 teams in the league, the New York Giants defense ranks an abysmal 29th in total passing yards allowed (277.5) to the quarterback position a game.
As I noted in the rules section above, selecting the correct player at the captain position for a Draftkings NFL Football showdown lineup is absolutely vital if you hope to win a large field GPP (guaranteed prize pool) DFS contest. Keep that in mind as you construct your lineups.
In my opinion, Patrick Mahomes is the most likely player to post the most Draftkings points in this NFL regular season game. For that specific reason, I am backing Kansas City Chiefs quarterback Patrick Mahomes at the captain position for this one game NFL DFS slate.
Flex plays I like to play well in this NFL regular season contest (Draftkings price noted): Russell Wilson, Quarterback (New York Giants) $9,400: Wan’Dale Robinson, Wide Receiver (New York Giants) $7,400: Tyquan Thornton, Wide Receiver (Kansas City Chiefs) $4,400.
