Draftkings NFL Showdown Picks: Patriots vs. Bills 10/5/25
New England Patriots vs. Buffalo Bills
October 5, 2025 8:20 pm EDT
The NFL presents Draftkings football fans with a regular season matchup featuring the New England Patriots and the Buffalo Bills. Let’s take a look at this game from a DFS perspective.
Before we dive into the New England Patriots vs. Buffalo Bills game let’s review the rules for the Draftkings single game showdown contest.
Draftkings Single Game Showdown Contest Rules
You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.
The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.
If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.
*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.
Here are my Draftkings picks for this Sunday’s Patriots vs. Bills matchup.
Draftkings NFL Showdown Picks
Josh Allen, Quarterback, Buffalo Bills
Talented quarterback Josh Allen has certainly been a standout performer for the Buffalo Bills in 2025. With that said, how has Allen performed from a data perspective this season? Let’s review Josh Allen’s relevant key player game data from the 2025 NFL season to better shed light on his overall contributions to his team.
In the four games that quarterback Josh Allen has played for the Buffalo Bills in the 2025 NFL regular season, Allen has amassed a robust 964 passing yards, seven passing touchdowns, 159 rushing yards and three rushing touchdowns.
Examining the data just presented more closely, in the four games that Josh Allen has played for the Bills this season, Allen has averaged 25.6 Draftkings points a contest.
More recently, in the Buffalo Bills 31-19 victory over the New Orleans Saints last week, Buffalo quarterback Josh Allen played rather well. Let me be more specific. In the Bills defeat of the Saints just mentioned, Allen compiled 209 passing yards, two passing touchdowns, 45 rushing yards and one rushing touchdown.
What did we learn? The data clearly illustrates that Josh Allen can post a high number of DFS points on any given night. Having stated that, I fully expect that trend to continue in this week’s regular season matchup with the New England Patriots.
As I noted in the rules section above, selecting the correct player at the captain position for a Draftkings NFL Football showdown lineup is absolutely vital if you hope to win a large field GPP (guaranteed prize pool) DFS contest. Keep that in mind as you construct your lineups.
In my view, Josh Allen is the most likely player to post the most Draftkings points in this NFL regular season game. For that specific reason, I am backing Buffalo Bills quarterback Josh Allen at the captain position for this one game NFL DFS slate.
Flex Plays
James Cook, Running Back, Buffalo Bills
In addition to Josh Allen, running back James Cook has been a key contributor for the Buffalo Bills this season.
In four games played in the 2025 NFL regular season, James Cook has tallied 401 rushing yards, five rushing touchdowns, 12 receptions and 89 receiving yards.
Flex plays I like to play well in this NFL regular season contest: Drake Maye, Quarterback (New England Patriots): Hunter Henry, Tight End (New England Patriots): Matt Prater, Kicker (Buffalo Bills).
