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Draftkings MLB DFS Picks: Royals vs. Giants 5/21/25

Kansas City Royals vs. San Francisco Giants
May 21, 2025 3:45 pm EDT

Major League Baseball presents Draftkings baseball fans with an interleague matchup featuring the Kansas City Royals and the San Francisco Giants. Let’s take a look at this MLB game from a DFS perspective.

Before we dive into the Kansas City Royals vs. San Francisco Giants game let’s review the rules for the Draftkings MLB single game showdown contest.

Draftkings Single Game Showdown Contest Rules

You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.

The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.

If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.

*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.

Here are my Draftkings picks for tonight’s Kansas City Royals vs. San Francisco Giants matchup.

Draftkings MLB Showdown Picks

Captain-Logan Webb, Starting Pitcher, San Francisco Giants $12,400

Later today, Major League Baseball presents the final game of a three-game interleague series featuring the Kansas City Royals and the San Francisco Giants.

How are these two teams playing entering tonight’s MLB game? The San Francisco Giants arrive at the third game of this three-game series with the Kansas City Royals playing good baseball. The Giants have won four of the team’s last five games played in the 2025 MLB regular season, including a 3-2 win over the Athletics three days ago.

Conversely, the Kansas City Royals are playing below average baseball entering the third game of this interleague series. The Royals have lost five of the team’s last seven games played this season, including a 4-3 loss to the Houston Astros last week.

Now that we have determined how both of these teams are currently playing let’s shift our focus to tonight’s contest. Starting pitcher Logan Webb has been a solid performer for the San Francisco Giants starting pitching rotation this season. With that said, how has Webb performed from a statistical perspective in 2025? Let’s review the veteran hurler’s relevant game data from the 2025 MLB regular season to answer that question.

Through ten starts made in 2025, San Francisco Giants starting pitcher Logan Webb has compiled a 5-3 (win-loss record), a 2.42 ERA (Earned Run Average) and a 1.12 WHIP (Walks and Hits per Inning Pitched). Additionally, Logan Webb has tallied 69 strikeouts while allowing 16 walks in 63.1 innings pitched this season.

More recently, in the San Francisco Giants dominant 9-1 victory over the Athletics five days ago, San Francisco starting pitcher Logan Webb pitched exceptionally well. More specifically, Webb pitched eight quality innings while scattering five hits and two walks in the Giants win over the Athletics.

In my view, Logan Webb is the most likely player to post the most Draftkings points in tonight’s MLB regular season game. Having stated that, I am backing San Francisco Giants starting pitcher Logan Webb at the captain position for this one game MLB DFS slate.

Flex plays I like to play well in this MLB regular season game (Draftkings price noted): Luinder Avila, Starting Pitcher (Kansas City Royals) $10,400: Heliot Ramos, Outfielder (San Francisco Giants) $7,800: Maikel Garcia, Third Baseman (Kansas City Royals) $8,800.

Hans Geevers's Free Pick: See Above

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Hans Geevers

I have been an avid fan of sports since I was a kid. Additionally, I have been betting on sports for the better part of the last two decades! I have been married to my wife Dawn for over 21 years. I am also the proud father of Hannah! These ladies provide me the inspiration to live each day to it's fullest.

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