Draftkings NFL DFS Picks: Seahawks vs. Cardinals 9/25/25
Seattle Seahawks vs. Arizona Cardinals
September 25, 2025 8:15 pm EDT
On Thursday night, the NFL presents Draftkings football fans with a regular season matchup featuring the Seattle Seahawks and the Arizona Cardinals. Let’s take a look at this game from a DFS perspective.
Before we dive into the Seattle Seahawks vs. Arizona Cardinals game let’s review the rules for the Draftkings single game showdown contest.
Draftkings Single Game Showdown Contest Rules
You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.
The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.
If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.
*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.
Here are my Draftkings picks for tomorrow night’s Seahawks vs. Cardinals matchup.
Draftkings NFL DFS Picks
Captain-Sam Darnold, Quarterback, Seattle Seahawks $10,000
Veteran quarterback Sam Darnold has been the driving force behind the Seattle Seahawks success on the offensive side of the football in 2025. With that said, how has Darnold performed from a statistical standpoint this season? Let’s review the talented signal caller’s relevant key player game data from the 2025 NFL regular season to answer that question.
In the three games that quarterback Sam Darnold has played for the Seattle Seahawks in the 2025 NFL regular season, Darnold has amassed 663 passing yards and four passing touchdowns.
More recently, in the Seattle Seahawks convincing 31-17 win over the Pittsburgh Steelers two weeks ago, Sam Darnold played rather well. In the Seahawks defeat of the Steelers just noted, Darnold tallied 295 passing yards and two passing touchdowns.
Looking closer at the data just presented, in the Seattle Seahawks victory over the Steelers, Sam Darnold compiled 17.8 Draftkings points.
What did we learn from the data just presented? The data clearly indicates that Sam Darnold has the potential to post a high number of DFS points on any given night. Having stated that I fully expect that trend to continue in tomorrow night’s matchup with the Arizona Cardinals.
I also like Sam Darnold’s matchup in this game. Why? The Arizona Cardinals defense has had issues containing the quarterback position in 2025. Let me be more specific. Upon the completion of three games played in the 2025 NFL regular season, in relation to the other 31 teams in the league, the Arizona Cardinals rank an abysmal 30th in total passing yards allowed (264.3) to the quarterback position a game.
In my opinion, Sam Darnold is the most likely player to post the most Draftkings points in this NFL regular season game. For that specific reason, I am backing Seattle Seahawks quarterback Sam Darnold at the captain position for this one game NFL DFS slate.
Flex Plays
Jaxson Smith-Njigba, Wide Receiver, Seattle Seahawks $11,000
In addition to Sam Darnold, wide receiver Jaxson Smith-Njigba has been a key contributor for the Seattle Seahawks this season.
In the three games that Jaxson Smith-Njigba has played for the Seattle Seahawks in the 2025 NFL regular season, Seattle starting quarterback Sam Darnold has targeted Jaxson Smith-Njigba a massive 29 times. In those 29 targets just mentioned, Smith-Njigba amassed 22 receptions, 323 receiving yards and one receiving touchdown.
Flex plays I like to play well in this NFL regular season contest (Draftkings price noted): Kyler Murray, Quarterback (Arizona Cardinals) $10,800: Trey McBride, Tight End (Arizona Cardinals) $9,800: Trey Benson, Running Back (Arizona Cardinals) $8,800: Tory Horton, Wide Receiver (Seattle Seahawks) $5,800.
