Draftkings NFL Showdown Picks: Titans vs. Cardinals 10/5/25
Tennessee Titans vs. Arizona Cardinals
October 5, 2025 4:05 pm EDT
On Sunday afternoon, the NFL presents Draftkings football fans with a regular season matchup featuring the Tennessee Titans and the Arizona Cardinals. Let’s take a look at this game from a DFS perspective.
Before we dive into the Tennessee Titan vs. Arizona Cardinals game let’s review the rules for the Draftkings single game showdown contest.
Draftkings Single Game Showdown Contest Rules
You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.
The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.
If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.
*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.
Here are my Draftkings picks for this week’s Titans vs. Cardinals matchup.
Draftkings NFL Showdown Picks
Captain-Kyler Murray, Quarterback, Arizona Cardinals $11,000
Veteran quarterback Kyler Murray has been the driving force behind the Arizona Cardinals success on the offensive side of the football in 2025. With that said, how has Murray performed from a statistical perspective this season? Let’s review the talented signal caller’s relevant key player game data from the 2025 NFL regular season to answer that question.
In the four games that quarterback Kyler Murray has played for the Arizona Cardinals in the 2025 NFL regular season, Murray has amassed 742 passing yards, six passing touchdowns and 148 rushing yards.
Looking closer at the data just presented, in the four games that Kyler Murray has played for the Arizona Cardinals this season, Murray is averaging 16.4 Draftkings points a contest.
More recently, in the Arizona Cardinals 20-13 win over the New Orleans Saints three weeks ago, Kyler Murray played rather well. More specifically, in the Cardinals defeat of the Saints just noted, Murray accumulated 163 passing yards, two passing touchdowns and 38 rushing yards.
As I noted in the rules section above, selecting the correct player at the captain position for a Draftkings NFL Football showdown lineup is absolutely vital if you hope to win a large field GPP (guaranteed prize pool) DFS contest. Keep that in mind as you construct your lineups.
In my view, Kyler Murray is the most likely player to post the most Draftkings points in this NFL regular season game. For that specific reason, I am backing Arizona Cardinals quarterback Kyler Murray at the captain position for this one game NFL DFS Showdown slate.
Flex Plays
Trey McBride, Tight End, Arizona Cardinals
In addition to quarterback Kyler Murray, tight end Trey McBride has been a key contributor for the Arizona Cardinals this season.
In the four games that tight end Trey McBride has played for the Arizona Cardinals in 2025, Arizona quarterback Kyler Murray has targeted McBride a whopping 35 times. In those 35 targets just noted, McBride compiled 24 receptions, 234 receiving yards and one receiving touchdown.
Flex plays I like to play well in this Sunday afternoon’s NFL regular season contest: Tony Pollard, Running Back (Tennessee Titans) $9,000: Marvin Harrison Jr., Wide Receiver (Arizona Cardinals) $9,400: Elic Ayomanor, Wide Receiver (Tennessee Titans) $7,200.
