FanDuel Best MLB DFS Picks: Cardinals vs. Giants 9/22/25
St. Louis Cardinals vs. San Francisco Giants
September 22, 2025 9:45 pm EDT
Major League Baseball presents FanDuel baseball fans with a National League matchup featuring the St. Louis Cardinals and the San Francisco Giants. Let’s take a look at this MLB game from a DFS perspective.
Before we dive into the St. Louis Cardinals vs. San Francisco Giants game let’s review the rules for the FanDuel single game showdown contest.
FanDuel Single Game Contest Rules
Here are the FanDuel single game contest rules. You have $60,000 to utilize on five players from either team. However, one of those players will be designated as your team MVP. The MVP accumulates 1.5x times the standard FanDuel fantasy points value. Additionally, the MVP is 1.5 times the standard cost of the flex position.
The remaining five players in your lineup will be flex plays. The five flex positions will receive the standard FanDuel points value. Having stated that, it is highly important for you to identify the correct player for your MVP position if you hope to win a large field GPP (guaranteed prize pool) FanDuel single game contest.
If you have additional questions regarding the rules for the single game contest, I highly recommend that you check out the FanDuel website for more details.
*It should be noted that FanDuel does not utilize the pitcher position in single game MLB contests. Having stated that, only batters are available for single game MLB lineups on the FanDuel platform.
Here are my FanDuel picks for tonight’s Cardinals vs. Giants matchup.
FanDuel MLB DFS Picks
MVP-Rafael Devers, Third Baseman, San Francisco Giants $12,400
On Monday night, Major League Baseball presents the opening game of a three-game National League series featuring the St. Louis Cardinals and the San Francisco Giants.
How are these two teams playing entering this evening’s National League contest? The San Francisco Giants arrive at the first game of this three-game series with the St. Louis Cardinals playing below average baseball. More specifically, the Giants have lost seven of the team’s last nine games played in the 2025 MLB regular season, including a 7-5 loss to the Los Angeles Dodgers two days ago.
In direct contrast to the San Francisco Giants, the St. Louis Cardinals are currently playing good baseball entering this evening’s game. The Giants have won three of the team’s last five games played in the 2025 MLB regular season, including a 3-0 shutout victory over the Cincinnati Reds last week.
Now that we have determined how both of these teams are currently playing let’s turn our attention to tonight’s contest. Third baseman Rafael Devers has been a solid performer for the San Francisco Giants starting lineup this season. With that said, how has the talented third baseman performed from a statistical perspective? Let’s review Devers’s relevant game data from the 2025 MLB regular season to answer that question.
In the 157 games that third baseman Rafael Devers has played in the 2025 MLB regular season, Devers has compiled a .251 batting average, 32 home runs (14th in MLB), 107 walks (third in MLB), 105 RBIs (runs batted in), 94 runs scored, an .839 OPS (On-base Plus Slugging) and a .370 OBP (On-Base Percentage) which ranks 11th in MLB.
In my view, Rafael Devers is the most likely player to accumulate the most FanDuel points in this MLB game. With that said, I am rolling with San Francisco Giants third baseman Rafael Devers at the MVP position for this one game MLB DFS slate.
Flex plays I like in this game (FanDuel price noted): Alec Burleson, Outfielder (St. Louis Cardinals) $9,800: Matt Chapman, Third Baseman (San Francisco Giants) $10,400: Nolan Arenado, Third Baseman (St. Louis Cardinals) $6,800.
