FanDuel MLB DFS Picks: Diamondbacks vs. Padres 9/27/25

Major League Baseball presents FanDuel baseball fans with a National League matchup featuring the Arizona Diamondbacks and the San Diego Padres. Let’s take a look at this MLB game from a DFS perspective.

Before we dive into the Arizona Diamondbacks vs. San Diego Padres game let’s review the rules for the FanDuel single game showdown contest.

FanDuel Single Game Contest Rules

Here are the FanDuel single game contest rules. You have $60,000 to utilize on five players from either team. However, one of those players will be designated as your team MVP. The MVP accumulates 1.5x times the standard FanDuel fantasy points value. Additionally, the MVP is 1.5 times the standard cost of the flex position.

The remaining five players in your lineup will be flex plays. The five flex positions will receive the standard FanDuel points value. Having stated that, it is highly important for you to identify the correct player for your MVP position if you hope to win a large field GPP (guaranteed prize pool) FanDuel single game contest.

If you have additional questions regarding the rules for the single game contest, I highly recommend that you check out the FanDuel website for more details.

*It should be noted that FanDuel does not utilize the pitcher position in single game MLB contests. Having stated that, only batters are available for single game MLB lineups on the FanDuel platform.

Here are my FanDuel picks for tonight’s Diamondbacks vs. Padres matchup.

FanDuel MLB DFS Picks

MVP-Fernando Tatis Jr., Outfielder, San Diego Padres $12,200

On Saturday night, Major League Baseball presents the second game of a three-game National League series featuring the Arizona Diamondbacks and the San Diego Padres.

How are these two teams playing entering today’s MLB game? The San Diego Padres arrive at the second game of this three-game series with the Arizona Diamondbacks playing good baseball. More specifically, the Padres have won five of the team’s last six games played in the 2025 MLB regular season, including a 7-0 shutout win over the Milwaukee Brewers four days ago.

In direct contrast to the San Diego Padres, the Arizona Diamondbacks are currently playing below average baseball entering this National League game. The Diamondbacks have lost three of the team’s last four games played in the 2025 MLB regular season, including a 5-4 loss to the Los Angeles Dodgers earlier this week.

Now that we have identified how both of these teams are currently playing let’s shift our attention to tonight’s contest. Outfielder Fernando Tatis Jr. has certainly been an essential part of the San Diego Padres starting lineup this season. With that said, how has the veteran outfielder performed from a statistical standpoint? Let’s examine Tatis Jr.’s relevant game data from the 2025 MLB regular season to answer that question.

In the 153 games that San Diego Padres outfielder Fernando Tatis Jr. has played in the 2025 MLB regular season, Tatis Jr. has compiled a .266 batting average, 24 home runs, 88 walks, 70 RBIs (runs batted in), 32 stolen bases (12th in MLB) and 109 runs scored (sixth in MLB). What did we learn from the data just presented? Clearly, Tatis Jr. is playing at a high-level entering tonight’s matchup with the Arizona Diamondbacks.

In my opinion, Fernando Tatis Jr. is the most likely player to accumulate the most FanDuel points in this MLB game. With that said, I am backing San Diego Padres outfielder Fernando Tatis Jr. at the MVP position for this one game MLB DFS slate.

Flex plays I like in this MLB game (FanDuel price noted): Jackson Merrill, Outfielder (San Diego Padres) $9,000: Geraldo Perdomo, Shortstop (Arizona Diamondbacks) $10,800.