FanDuel MLB DFS Picks: White Sox vs. Red Sox 4/21/25

Major League Baseball presents FanDuel baseball fans with an American League matchup featuring the Chicago White Sox and the Boston Red Sox. Let’s take a look at this MLB game from a DFS perspective.

Before we dive into the Chicago White Sox vs. Boston Red Sox game let’s review the rules for the FanDuel single game showdown contest.

FanDuel Single Game Contest Rules

Here are the FanDuel single game contest rules. You have $60,000 to utilize on five players from either team. However, one of those players will be designated as your team MVP. The MVP accumulates 1.5x times the standard FanDuel fantasy points value. Additionally, the MVP is 1.5 times the standard cost of the flex position.

The remaining five players in your lineup will be flex plays. The five flex positions will receive the standard FanDuel points value. Having stated that, it is highly important for you to identify the correct player for your MVP position if you hope to win a large field GPP (guaranteed prize pool) FanDuel single game contest.

If you have additional questions regarding the rules for the single game contest, I highly recommend that you check out the FanDuel website for more details.

*It should be noted that FanDuel does not utilize the pitcher position in single game MLB contests. Having stated that, only batters are available for single game MLB lineups on the FanDuel platform.

Here are my FanDuel picks for tomorrow’s White Sox vs. Red Sox matchup.

FanDuel MLB Player Selections

MVP-Jarren Duran, Outfielder, Boston Red Sox $9,000

On Monday, Major League Baseball presents the final game of a four-game American League series featuring the Chicago White Sox and the Boston Red Sox.

How are these two teams playing entering tomorrow’s American League game? The Chicago White Sox arrive at the fourth game of this four-game series with the Boston Red Sox playing below average baseball. Let me be more specific. The White Sox have lost six of the team’s last seven games played in the 2025 MLB regular season, including a 10-3 loss to the Boston Red Sox two days ago.

In direct contrast to the Chicago White Sox, the Boston Red Sox are currently playing good baseball entering this MLB game. The Red Sox have won five of the team’s last six games played in the 2025 MLB regular season, including a 1-0 shutout win over the Tampa Bay Rays earlier this week.

Now that we have determined how both of these teams are currently playing let’s shift our focus to this American League contest. Outfielder Jarren Duran has been a solid performer for the Boston Red Sox this season. With that said, how has the veteran outfielder performed from a statistical standpoint? Let’s examine Duran’s relevant game data from the 2025 MLB regular season to answer that question.

In the 19 games that Boston Red Sox outfielder Jarren Duran has played in the 2025 MLB regular season, Duran has compiled a robust .235 batting average, 22 hits, one home run, seven walks, 11 RBIs (runs batted in) and nine runs scored.

Five days ago, in the Boston Red Sox’s 7-4 win over the Tampa Bay Rays, Boston outfielder Jarren Duran certainly played at a high level. More specifically, in the Boston Red Sox’s victory over the Rays, Duran amassed one hit, two RBIs, two runs scored and one home run. It should also be mentioned that in the Red Sox’s defeat of the Rays, Duran compiled a whopping 37.4 FanDuel points.

In my view, Jarren Duran’s low FanDuel price of only $9,000 presents the best fantasy value on this MLB DFS slate. For that specific reason, I am rolling with Boston Red Sox outfielder Jarren Duran at the MVP position for this one game FanDuel MLB DFS slate.

Flex plays I like in this game (FanDuel price noted): Rafael Devers, Third Baseman (Boston Red Sox) $9,400: Luis Robert Jr., Outfielder (Chicago White Sox) $10,000: Trevor Story, Shortstop (Boston White Sox) $11,800.