Angels vs Astros Prediction 9/28/25 MLB Picks Today

The Houston Astros and Los Angeles Angels meet Sunday in MLB action at Angel Stadium. Here’s a Angels vs Astros Prediction. This article will include a Angels vs Astros Pick.

Houston Astros Betting Preview

The Houston Astros are 86-74 on the year after playing the Athletics. The Houston Astros are batting .250 on the season, have a .315 OBP, and a .397 slugging percentage. The Houston Astros pitching staff has a 3.88 ERA and a 1.23 WHIP. Jose Altuve leads the Houston Astros with 156 hits and 77 RBI while Jeremy Pena and Christian Walker have combined for 289 hits and 150 RBI.

Lance McCullers Jr.  gets the ball for the Houston Astros, and he is 2-5 with a 6.71 ERA and 57 strikeouts this season. McCullers is 7-5 with a 3.09 ERA and 116 strikeouts in his career against the Los Angeles Angels.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 72-89 on the year after playing the Royals. The Los Angeles Angels are batting .226 on the season, have a .298 OBP, and a .398 slugging percentage. The Los Angeles Angels pitching staff has a 4.88 ERA and a 1.43 WHIP. Taylor Ward leads the Los Angeles Angels with 131 hits and 103 RBI while Zach Neto and Nolan Schanuel have combined for 258 hits and 115 RBI.

Sam Aldegheri gets the ball for the Houston Astros, and he is 0-1 with a 8.00 ERA and 7 strikeouts this season. This will be Aldegheri’s second career game against the Los Angeles Angels.

Houston Astros @ Los Angeles Angels Betting Trends: September 28, 2025

• Probable Starting Pitcher: Samuel Aldegheri      Record this season: 0-1      ERA: 8.00
• Home Record: 0-1
• Last 5 against Astros: 0-1

Why the Los Angeles Angels will win

• The Astros have lost each of their last six day games against American League opponents following a win.
• The Angels have won eight of their last nine games against AL West opponents following a home loss.
• The Angels have covered the run line in eight of their last nine games against AL West opponents following a home loss.
• The Astros have failed to cover the run line in seven of their last eight games against AL West opponents following a road win.
• The Astros have trailed after 3 innings in three of their last four day games.
• The Angels have led after 5 innings in each of their last three day games at Angel Stadium of Anaheim against AL West opponents.

• Probable Starting Pitcher: Lance McCullers Jr.      Record this season: 2-5      ERA: 6.71
• Road Record: 2-1
• Last 5 against Angels: 3-1

Why the Houston Astros will win

• The Angels have lost 12 of their last 14 day games against American League opponents that held a winning record.
• The Astros have won 12 of their last 16 road games against the Angels.
• The Angels have failed to cover the run line in 10 of their last 13 games.
• The Astros have covered the run line in three of their last four day games against American League opponents that held a losing record.
• The Angels have trailed after 3 innings in three of their last four day games against American League opponents that held a winning record.
• The Angels have trailed after 5 innings in seven of their last eight games against American League opponents.

Total Runs Facts

• Eight of the Astros’ last nine road games against American League opponents have gone UNDER the total runs line.
• Five of the last six games between the Astros and Angels have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last eight games between the Astros and Angels.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four games at Angel Stadium of Anaheim.

Los Angeles Angels Player Prop Facts

• Taylor Ward has recorded at least one hit in each of his last seven appearances after playing the previous day.
• Mike Trout has hit at least one home run in two of the Angels’ last three games.

Houston Astros Player Prop Facts

• Christian Walker has recorded at least one hit in each of the Astros’ last 21 road games against opponents that held a losing record.
• Christian Walker has hit at least one home run in each of the Astros’ last three games.

Angels vs Astros Prediction

Neither the Angels nor Astros care about this game now that they’re out of the playoff race. Throw in care free ball and two struggling pitchers, and we should see some offense. McCullers has a 6.71 ERA and 1.85 WHIP on the season, and he’s allowed 11 hits and 5 earned runs in his last 8 innings. Aldegheri has just 9 innings under his belt and has allowed 13 hits and 8 runs in those frames while walking 7. Expect some offense. Forget the side and give me the over.