Angels vs Athletics Prediction 5/21/25 MLB Picks Today

The Los Angeles Angels are visiting the Athletics on Wednesday, May 21^st at the Sutter Health Park in the third game of this series, with the Angels having a 2-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Angels vs Athletics Prediction. We will examine:

The Athletics’ recent form and player performance

The Los Angeles Angels’ recent form and player performance

Recent betting trends and streaks involving the Athletics

Recent betting trends and streaks involving the Los Angeles Angels

Recent betting trends in games played between the Los Angeles Angels vs Athletics

A summary that ties it all together and produces a favorable betting outcome for the Los Angeles Angels vs Athletics game

Athletics Preview

The Athletics have a 22-27 record this season and are sitting in 4^th place in the AL West. The Athletics have an 8-15 home record and are 25-20 in over/under. They are coming off a 5-7 home defeat by the Athletics, and are 2-11 in their last 13 games. Under is 3-1 in their last 5 games, and they are playing the Phillies and the Astros next.

The Athletics have a .252 batting average this season, a .313 OBP, and a .414 Slugging percentage. Athletics’ pitching staff has a 5.14 ERA and 1.48 WHIP. Jacob Wilson leads the Athletics with 62 hits and a team-high .341 batting average, while Tyler Soderstrom leads the team with 30 RBI, and Brent Booker adds a team-high 10 home runs.

JP Sears (L) will take the mound for the Athletics, and he has a 4-3 record, 3.31 ERA, and 1.10 WHIP. He has a 3.86 ERA in his three home starts, but he is coming off his worst start of the season, where he gave up 4 runs in 4 innings pitched. JP Sears is 3-2 with an ERA of 3.86 and 24 strikeouts in 6 appearances against the Angels in his career.

Los Angeles Angels Preview

The Los Angeles Angels have a 22-25 record this season and are sitting in last place in the AL West. The Angels have a 13-15 road record and 27-20 in over/under. They are coming off a 7-5 road victory over the Athletics and have five consecutive wins. Over is 6-3 in their last 9 games, and they are playing the Marlins and the Yankees next.

The Angels have a .222 batting average this season, a .283 OBP, and a .403 Slugging percentage. LA’s pitching staff has a 5.04 ERA and 1.49 WHIP. Nolan Schanuel leads the Angels with 44 hits, and he is the team’s best hitter with a .277 batting average. Taylor Ward leads the team with 28 RBI and a team-high 13 home runs.

Jack Kochanowicz (R) will take the mound for the Angels, and he has a 3-5 record, 4.71 ERA, and 1.47 WHIP. He has been weaker on the road with a 5.14 ERA across five road starts, and he has been in great form lately, with just two earned runs in 11.4 innings pitched across his last two starts. In his only previous start against the Athletics last season, he got torched for 7 earned runs in 4 innings pitched as the Angels lost 2-8.

Why the Athletics will win

• The Angels have lost each of their last nine Wednesday road games.
• The Athletics have won five of their last six night games against AL West opponents following a home loss.
• The Athletics have covered the run line in five of their last six night games against AL West opponents following a home loss.
• The Angels have failed to cover the run line in nine of their last 11 road games against American League opponents.
• The Angels have lost the first inning in four of their last five road games against American League opponents that held a losing record.
• The Angels have trailed after 5 innings in each of their last seven Wednesday night road games.
• The Angels have trailed after 3 innings in eight of their last nine road games against American League opponents.

Why the Los Angeles Angels will win

• The Athletics have lost each of their last eight games after playing the previous day.
• The Angels have won each of their last five games as underdogs.
• The Athletics have failed to cover the run line each of their last nine home games against teams that held a losing record.
• The Angels have covered the run line in each of their last five games.
• The Angels have led after 5 innings in each of their last five games.
• The Angels have led after 3 innings in four of their last five games.

Total Runs Facts

• Five of the Athletics’ last six home games have gone OVER the total runs line.
• Four of the Angels’ last five games as underdogs against the Athletics have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Angels’ last seven games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Athletics’ last six games against AL West opponents.

Matchup/League Facts

• The Athletics rank 30th in the league for walks allowed this season (194).
• The Athletics rank 29th in the league for hits allowed this season (452).
• The Angels rank 30th in the league for on-base percentage this season (.283).
• The Angels rank 30th in the league for walks this season (118).

Angels vs Athletics Prediction

The Angels are 3-0 in their last 3 meetings against the A’s, but the Athletics are 8-4 in their last 12 overall meetings, and are 5-3 in their last 8 meetings in Oakland. Over is 6-3 in their last 9 meetings.

In this Angels vs Athletics Prediction, the Athletics are coming as -160 home favorites. Both teams have identical records this season, but the A’s have been terrible at home, while the Angels are mediocre on the road. The A’s have the pitching advantage in this matchup, as Sears has been a far more reliable option than Kochanowicz, and the Angels have the worst bullpen in the MLB with a 6.82 ERA and 1.71 WHIP. The Angels are also much weaker against lefties, with just 2.9 runs/9 and a .193 batting average, so this screams as a bounce-back spot for the A’s. Take the Athletics on the moneyline.