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Angels vs Giants Prediction 4/18/25 MLB Picks Today

San Francisco Giants (13-6) vs. LA Angels (9-9)
April 18, 2025 9:38 pm EDT
The Line: LA Angels +130 / San Francisco Giants -155; Over/Under: 8
(Get latest betting odds)

The San Francisco Giants and the Los Angeles Angels meet Friday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Angels vs Giants Prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Logan Webb for the start here and is 2-0 with a 2.63 ERA and 26 strikeouts this season. This will be Webb’s second career start against the Angels. Tyler Anderson will start for the Angels and is 1-0 with a 2.87 ERA and 15 strikeouts this season. In his last five starts against the Giants, Anderson is 3-0 with a 4.13 ERA and 24 strikeouts.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to rebound from a 6-4 loss in Thursday’s series finale against the Philadelphia Phillies to fall to 13-6 on the year. After this series, the Giants will head home for a series against the Milwaukee Brewers.

Giants Settle For Split Vs. Phillies

Jung Hoo Lee leads the Giants with 24 hits including a team-high 10 doubles along with 3 home runs and 14 RBIs with 3 stolen bases while Heliot Ramos has 18 hits with 6 doubles, 3 home runs and 9 RBIs. Wilmer Flores also has a team-high 6 home runs and 23 RBIs while Mike Yastrzemski has 3 home runs with 11 RBIs and 5 doubles and Tyler Fitzgerald has a team-high 4 stolen bases as well on the year.

Why the San Francisco Giants will win

  • The Giants have won each of their last seven road games following a loss.
  • The Angels have lost 10 of their last 11 night games following a road loss.
  • The Giants have covered the run line in each of their last 10 night games against American League opponents.
  • The Angels have failed to cover the run line in 10 of their last 11 night games following a road loss.

San Francisco Giants Player Prop Facts

  • Heliot Ramos has hit a home run in three of the Giants’ last four games as road favorites.
  • Jung Hoo Lee has recorded at least one Double in four of his five previous appearances against AL West opponents.
  • Wilmer Flores has recorded at least one RBI in each of the Giants’ last four night games.
  • Matt Chapman has recorded at least one Single in each of the Giants’ last four games.
  • Logan Webb has recorded a win in each of his last four appearances against AL West opponents.
  • Heliot Ramos has scored a run in each of the Giants’ last six games as road favorites.
  • Logan Webb has recorded six or more strikeouts in each of his last four appearances with the Giants as favorites against AL opponents.
  • Matt Chapman has recorded at least one hit in each of his last nine road appearances against the Angels after playing the previous day.
  • Wilmer Flores ranks T4th in the league in Home Runs (6) this season.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to rebound after a 5-3 loss at the hands of the Texas Rangers last time out to slip to 9-9 on the year. After this series, the Angels will take on the Pittsburgh Pirates at home.

Angels Swept By Rangers

Logan O’Hoppe has 16 hits including 5 home runs and 9 RBIs while Nolan Schanuel has 19 hits with 3 doubles, a triple, 2 home runs and 7 RBIs. Luis Rengifo has a team-high 5 doubles with his 16 hits and Taylor Ward also has 18 hits as well while Mike Trout’s added 6 home runs and 14 RBIs so far this season. Jorge Soler also has 4 home runs, but also has the unfortunate distinction of leading the Angels with 24 strikeouts so far this season. Kyren Paris has also chipped in 15 hits with a triple, 5 home runs and 8 RBIs.

Why the Los Angeles Angels will win

  • The Angels have won seven of their last eight games as underdogs against National League opponents following a road loss.
  • The Giants have lost 10 of their last 15 games as road favorites against American League opponents.
  • The Angels have covered the run line in seven of their last eight games as underdogs against National League opponents following a road loss.
  • The Giants have failed to cover the run line in nine of their last 10 Friday games as favorites against American League opponents.

Los Angeles Angels Player Prop Facts

  • Mike Trout has hit a home run in four of his last five home appearances against the Giants.
  • Tyler Anderson has recorded a win in each of his last three appearances against the Giants.
  • Logan O’Hoppe has scored at least one run in each of his last six appearances with the Angels as home underdogs.
  • Mike Trout has recorded at least one RBI in five of his last six home appearances against the Giants.
  • Jorge Soler has recorded at least one hit in each of his last eight appearances against NL West opponents.
  • Tyler Anderson has recorded five or more strikeouts in eight of his last 10 appearances against former teams.
  • Yoan Moncada has recorded a Double in three of his last four appearances with his team as a home underdog.
  • Anthony Rendon has recorded at least one Single in seven of his last eight appearances against the Giants.
  • Mike Trout ranks T4th in the league in Home Runs (6) this season.

Total Runs Facts

  • Each of the Giants’ last eight games have gone OVER the total runs line.
  • Each of the Angels’ last four games as underdogs against National League opponents have gone OVER the total runs line.

Angels vs Giants Prediction

I’m on the Giants here. I’m just going to continue rolling with the Giants as long as this team continues to provide betting value on the road. I’m not going to hold anything against the Giants after a series split with a tough Phillies team, but the Angels, after a hot start, have regressed back to a team that’s struggling to drum up consistent offense on a night to night basis. I think the Giants snag the win and get the value on the road again, so give me San Francisco here.

Chris Ruffolo's Free Pick: San Francisco Giants -155

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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