Angels vs Guardians Prediction 4/4/25 MLB Picks Today

The Cleveland Guardians and the Los Angeles Angels meet Friday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Los Angeles Angels prediction.

Starting Pitching Matchup

The Cleveland Guardians will trot out Gavin Williams for the start here and Williams is 0-0 with a 3.60 ERA and 2 strikeouts so far this season. This will be Williams’ first career start against the Angels. Jose Soriano will get the start for the Los Angeles Angels in this one and is 1-0 with a 0.00 ERA and 5 strikeouts so far this season. In his career, Soriano is 1-1 with a 3.00 ERA and 11 strikeouts against Cleveland.

Cleveland Guardians Recap

The Cleveland Guardians come into this set looking to bounce back after a 5-2 loss to the San Diego Padres in Wednesday’s series finale, ending up on the wrong side of a three-game sweep to slip to 2-4 on the year. After this series, the Guardians will head home for the start of a division series against the Chicago White Sox.

Guardians Drop Third In A Row

Steven Kwan leads the Guardians with 8 hits as part of a .348 batting average and a home run, a double and three RBIs. Kyle Manzardo has 5 hits with a double, a triple, 2 home runs and a team-high 7 RBIs as well this year. Jose Ramirez, Carlos Santana and Nolan Jones each have a team-high 2 doubles as well this season. Jones and Bo Naylor share the unfortunate team lead with 7 strikeouts so far this year.

Why the Cleveland Guardians will win

• The Angels have lost each of their last seven night games against American League opponents.
• The Guardians have won each of their last five games against the Angels.
• The Angels have failed to cover the run line in each of their last seven games against AL Central opponents.
• The Guardians have covered the run line each of their last four road games against AL West opponents that held a winning record.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last four games against the Angels.
• Carlos Santana has recorded at least one RBI in seven of his last eight appearances against the Angels.
• Jose Ramirez has scored at least one run in each of the Guardians’ last five games against the Angels.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last seven games as road favorites against AL opponents.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 10 road games against AL opponents.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.

Los Angeles Angels Recap

The Los Angeles Angels come into this game hoping to bounce back from a 12-5 loss to St. Louis in Wednesday’s series finale to fall to 4-2 on the year. Despite that loss, the Angels have still won back-to-back series to start the year and after this set, the Guardians will hope to win another when they head to Tampa Bay to take on the Rays.

Angels Have Four-Game Win Streak Snapped

Nolan Schanuel has a team-high 7 hits with a double, a triple and 3 RBIs while Logan O’Hoppe has a team-high 2 home runs and 5 RBIs as well on the year. Mike Trout’s added a home run and 5 RBIs of his own while Taylor Ward, Luis Rengifo, Jorge Soler and Yoan Moncada all have a double as well on the year. Soler has the dubious distinction of leading the Halos with 8 strikeouts.

Why the Los Angeles Angels will win

• The Guardians have lost each of their last six games at Angel Stadium of Anaheim against AL West opponents that held a winning record.
• The Angels have won each of their last three games as home underdogs against AL Central opponents.
• The Guardians have failed to cover the run line each of their last seven road games against teams that held a winning record.
• The Angels have covered the run line in seven of their last eight games against the Guardians following a loss.

Los Angeles Angels Player Prop Facts

• Jorge Soler has recorded at least one RBI in seven of his last eight appearances against opponents that held a losing record.
• Luis Rengifo has scored at least one run in each of his last seven appearances with the Angels as home underdogs against AL Central opponents.
• Yoan Moncada has recorded at least one hit in each of his last 13 home appearances against opponents that held a losing record.
• Travis d’Arnaud has hit a home run in each of his last two appearances with his team as an underdog against AL opponents.
• Tim Anderson has recorded at least one Single in each of his last seven appearances at Angel Stadium of Anaheim against opponents that held a losing record.
• Anthony Rendon has recorded a Double in each of his four previous appearances against the Guardians after not playing the previous day.
• Jose Soriano ranks T1st amongst qualified players for Earned Run Average (0.00) this season.

Total Runs Facts

• Seven of the Angels’ last eight games against AL Central opponents have gone UNDER the total runs line.
• Each of the Guardians’ last three games against AL West opponents have gone UNDER the total runs line.

Cleveland Guardians vs. Los Angeles Angels Prediction

I’m on the under in this game. I get the case to be made for either side, but the thing here is that I think this is a low-scoring game, not because of outstanding pitching, but because of two offenses that are hitting below .200 against right-handed pitching so far this season. Soriano’s been really good to begin with and I think this is an awesome matchup for Williams to have some success. Give me the under here.