Angels vs Padres Prediction 5/13/25 MLB Picks Today

The Los Angeles Angels are visiting the San Diego Padres on Tuesday, May 13^th at the PETCO Park in the second game of this series, with the Angels leading the series 1-0 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Angels vs Padres Prediction. We will examine:

The San Diego Padres recent form and player performance

The Los Angeles Angels recent form and player performance

Recent betting trends and streaks involving the San Diego Padres

Recent betting trends and streaks involving the Los Angeles Angels

Recent betting trends in games played between the Los Angeles Angels vs San Diego Padres

A summary that ties it all together and produces a favorable betting outcome for Los Angeles Angels vs San Diego Padres game

San Diego Padres Preview

The San Diego Padres have a 25-15 record this season and are sitting on the second place of the NL West. They have a 14-5 home record, and are 18-21 in over/under. The Padres are coming off a 5-9 home defeat by the Angels, and have back-to-back losses. Their last four game have gone over the total, and are playing the Mariners and the Blue Jays next.

The Padres have a .266 batting average this season, .332 OBP and .403 Slugging percentage. San Diego’s pitching staff has a 3.37 ERA and 1.18 WHIP.  Manny Machado leads the Padres with 49 hits and team-high .331 batting average. Fernando Tatis Jr leads the team both in RBI, with 24, and in home runs, with 10.

Dylan Cease (R) will take the mound for the Padres, and he has a 1-2 record, 4.91 ERA and 1.41 WHIP. He has been better at home, with a 3.48 ERA across four home starts. He has been hit up by the Angels last season, having given up 6 runs in 12 innings of work across two starts, as the Padres lost both games.

Los Angeles Angels Preview

The Los Angeles Angels have a 17-23 record this season and are sitting on the last place of the AL West. The Angels have an 8-13 road record and 23-17 in over/under They are coming off a 9-5 road victory over the Padres, ending their previous nine-game road losing streak. Over is 8-3 in their last 11 games and are playing the Dodgers and the Athletics next.

The Angels have a .216 batting average this season, .276 OBP and .387 Slugging percentage. LA’s pitching staff has a 5.14 ERA and 1.49 WHIP. Nolan Schanuel leads the Angels with 33 hits, while Taylor Ward leads the team with 21 RBI. Logan O’Hoppe is the team’s best hitter with a .264 batting average.

Jose Soriano (R) will take the mound for the Angels, and he has a 2-4 record, 4.00 ERA and 1.53 WHIP. He has been better on the road, with a 2.49 ERA across four road starts. He has been struggling lately, having given up 3+ runs in four of his last five starts.

Why the San Diego Padres will win

• The Angels have lost nine of their last 10 road games.
• The home team has won seven of the last eight games between the Angels and Padres.
• The Angels have failed to cover the run line in nine of their last 10 road games.
• The Padres have covered the run line in eight of their last 10 games as favorites against AL West opponents following a home loss.
• The Angels have trailed after 5 innings in each of their last eight road games against NL West opponents that held a winning record.
• The Angels have trailed after 3 innings in each of their last eight road games.

Why the Los Angeles Angels will win

• The Padres have lost each of their last five games as favorites against American League opponents.
• The Angels have won each of their last four games as underdogs against the Padres.
• The Padres have failed to cover the run line each of their last seven night games against American League opponents that held a losing record.
• The Angels have covered the run line each of their last six night games against National League opponents that held a winning record.
• The Angels have led after 5 innings in three of their last four night games against opponents that held a winning record.
• The Angels have led after 3 innings in three of their last four night games against opponents that held a winning record.

Total Runs Facts

• Each of the Angels’ last five road games against National League opponents have gone OVER the total runs line.
• Each of the Padres’ last four games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last seven games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Angels’ last five games.

Matchup/League Facts

• The Padres rank 1st in the league for strikeouts against this season (271).
• The Padres rank 2nd in the league for batting average this season (.266).
• The Angels rank 30th in the league for on-base percentage this season (.276).
• The Angels rank 30th in the league for walks this season (98).

Angels vs Padres Prediction

The Angels are 4-0 in their last four meetings against the Padres, and under is 4-1 in their last 5 meetings. In this Angels vs Padres Prediction, the Padres are coming as -200 home favorites. The Padres are rightfully favored, as they have been the better team this season, and have been one of the best home teams in the MLB, while the Angels are terrible on the road.

But I am not willing to lay -200 with the Padres with Cease on the mound who has been struggling this season, and was shelled by the Angels last season. Both pitchers have a combined 8.91 ERA and the Angels have the second-worst bullpen in the MLB. Both teams are also better in hitting righties, averaging 5.2 and 4.1 runs against righties, and are 12-3 to the over in their last 15 games combined. With the total set at just 7.5 runs, I will gladly go over the total.