Angels vs Rockies Prediction 9/21/25 MLB Picks Today

In this article, we will formulate an Angels vs Rockies Prediction for this MLB game on Sunday, September 21^st at the Coors Field in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Colorado Rockies Preview

The Colorado Rockies have a 42-113 record this season and are sitting on the last place of the NL West. The Rockies have a 24-56 home record and are 69-81 in over/under. They are coming off a 0-3 home defeat by the Angels, and are 1-6 in their last 7 games. Over is 6-1 in their last 7 games, and are playing the Mariners and the Giants next.

The Rockies have a .239 batting average this season, .295 OBP and .389 Slugging percentage. Colorado’s pitching staff has a 6.02 ERA and 1.59 WHIP. Hunter Goodman leads the Rockies with 144 hits, also leading the team both in RBI, with 88, and in home runs, with 30. He is also the team’s best hitter with a .281 batting average.

Kyle Freeland (R) is the projected starting pitcher for the Rockies, and he has a 4-16 record, 5.14 ERA and 1.47 WHIP.

Los Angeles Angels Preview

The Los Angeles Angels have a 70-85 record this season and are sitting on the 4^th place of the AL West. The Angels have a 33-47 road record and 85-67 in over/under They are coming off a 3-0 road victory over the Rockies, that ended their seven-game losing streak. Over is 5-2 in their last 7 games and are playing the Astros and the Royals next.

The Angels have a .226 batting average this season, .299 OBP and .399 Slugging percentage. LA’s pitching staff has a 4.87 ERA and 1.44 WHIP. Zach Neto leads the Angels with 129 hits, while Nolan Schanuel is the team’s best hitter with a .268 batting average. Taylor Ward leads the team with 101 RBI, while Jo Adell adds a team-high 36 home runs.

Caden Dana (L) is the projected starting pitcher for the Angels, and he has a 0-2 record, 7.45 ERA and 1.86 WHIP.

Los Angeles Angels @ Colorado Rockies Betting Trends: September 21, 2025

• Probable Starting Pitcher: Kyle Freeland      Record this season: 4-16      ERA: 5.14
• Home Record: 2-7
• Last 5 against Angels: 2-0

Why the Colorado Rockies will win

• The Angels have lost 15 of their last 18 games as road favorites.
• The Rockies have won five of their last six games as underdogs against the Angels following a loss.
• The Angels have failed to cover the run line in 17 of their last 18 games as road favorites.
• The Rockies have covered the run line in each of their last four games against AL West opponents following a loss.
• The Rockies have won the first inning in three of their last four home games against American League opponents.
• The Angels have trailed after 5 innings in each of their last five day games against NL West opponents that held a losing record.

• Probable Starting Pitcher: Caden Dana      Record this season: 0-2      ERA: 7.45
• Road Record: 0-1
• Last 5 against Rockies: –

Why the Los Angeles Angels will win

• The Rockies have lost eight of their last nine home games after playing the previous day.
• The Angels have won nine of their last 11 games against NL West opponents.
• The Rockies have failed to cover the run line in eight of their last nine home games after playing the previous day.
• The favorites have covered the run line in six of the Angels’ last seven games.
• The Rockies have trailed after 3 innings in each of their last four day games.
• The Rockies have lost the first inning in three of their last four day games.
• The Rockies have trailed after 5 innings in eight of their last nine day games against opponents that held a losing record.

Total Runs Facts

• Six of the Rockies’ last seven games have gone OVER the total runs line.
• Eight of the Angels’ last 10 games against NL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Rockies’ last nine day games against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Angels’ last seven road games against NL West opponents.

Colorado Rockies Player Prop Facts

• Kyle Freeland has recorded five or more strikeouts in three of his last four appearances against AL West opponents.
• Kris Bryant has hit a home run in six of his last 22 home appearances against AL opponents.
• Tyler Freeman has recorded at least one Double in five of his last six home appearances against AL opponents that held a losing record.
• Ezequiel Tovar has recorded at least one hit in each of his last seven appearances in day games against AL teams that held a losing record.

Los Angeles Angels Player Prop Facts

• Zach Neto has hit a home run in four of his last five road appearances against opponents that held a losing record.
• Taylor Ward has recorded at least one hit in each of the Angels’ last 12 games as road favorites.
• Jo Adell ranks 9th in the league in Home Runs (36) this season.

Matchup/League Facts

• The Rockies rank 30th in the league for on-base percentage this season (.295).
• The Rockies rank 30th in the league for walks this season (380).
• The Angels rank 30th in the league for doubles this season (206).
• The Angels rank 30th in the league for batting average this season (.226).

Angels vs Rockies Prediction

The Rockies are 4-2 in their last 6 head-to-head meetings the Angels, but both teams are tied 3-3 wins in their last 6 meetings in Colorado. Over is 7-4 in their last 11 meetings.

In this Angels vs Rockies Prediction, the Angels are coming as -115 road favorites. I don’t trust Caden Dana for the Angels, as he has been horrendous in his 3 starts this season, and has 10 earned runs in just 7.4 innings pitched in his last two starts. On the flip side, Freeland has been terrible at home for the Rockies, with a 6.14 home ERA, and he was torched in his last start, with 6 earned runs against the Marlins. Both teams are also on the bottom-4 of the league in bullpen ERA, so I am expecting fireworks offensively in this one. Take the over 12 runs.