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Diamondbacks vs White Sox Prediction 4/23/26 MLB Picks Today

Chicago White Sox (9-15) vs. Arizona Diamondbacks (14-10)
April 23, 2026 3:40 pm EDT
The Line: Arizona Diamondbacks -156 / Chicago White Sox +129; Over/Under: 9
(Get latest betting odds)

The Chicago White Sox and the Arizona Diamondbacks meet Thursday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs. White Sox Prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Davis Martin and Martin is 3-1 with a 2.16 ERA and 19 strikeouts this season. This will be Martin’s second career start against the Diamondbacks. Michael Soroka will start for Washington here and Soroka is 4-0 with a 2.78 ERA and 28 strikeouts this season. This will be Soroka’s first career start against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from an 11-7 loss at the hands of the Diamondbacks in Wednesday’s matchup to sit at 9-15 this season. After this series, the White Sox will head home for a series against the Washington Nationals.

White Sox Have Two-Game Win Streak Snapped

Entering Wednesday, Munetaka Murakami has 18 hits with 9 home runs and 17 RBIs, while Miguel Vargas has 14 hits with 3 doubles, a triple, 4 home runs and 11 RBIs, and Colson Montgomery has 17 hits with 5 doubles, 6 home runs and 16 RBIs. Luisangel Acuña has 12 hits and Tristan Peters has 12 hits with a double so far this season. Chase Meidroth also has 20 hits with 5 doubles, a home run and 2 RBIs this year.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to build on their win over the White Sox from Wednesday to improve to 13-10 this season. After this series, the Diamondbacks will take on the San Diego Padres in a series at home.

Diamondbacks Snap Two-Game Slide

Going into Wednesday, Corbin Carroll has 21 hits, including 6 doubles, 3 triples, 3 home runs and a team-high 16 RBIs, while Alek Thomas has logged 7 doubles with 8 RBIs as well this season. Ketel Marte has 19 hits with 2 doubles, 4 home runs and 9 RBIs, and Geraldo Perdomo has 17 hits, with 3 doubles, a home run and 5 RBIs as well this season. Gabriel Moreno also has 11 hits with 5 doubles and Jose Fernandez has 19 hits with 2 home runs and 9 RBIs this season. Ildemaro Vargas also has 22 hits with 5 doubles, a triple, 3 home runs and 11 RBIs.

Why the Arizona Diamondbacks will win

  • The White Sox have lost each of their last eight Thursday games against teams that held a winning record.
  • The Diamondbacks have won six of their last seven games against AL Central opponents.
  • The Diamondbacks have covered the run line in seven of their last eight games against AL Central opponents.
  • The White Sox have failed to cover the run line in four of their last five games against National League opponents after playing the previous day.
  • The Diamondbacks have led after 5 innings in six of their last seven games as favorites against American League opponents.

 

  • Probable Starting Pitcher: Davis Martin      Record this season: 3-1      ERA: 2.16
  • Road Record: 2-1
  • Last 5 against Diamondbacks: 0-1

Why the Chicago White Sox will win

  • The White Sox have won four of their last five games as road underdogs following a loss.
  • The Diamondbacks have lost four of their last six games as home favorites against AL Central opponents following a win.
  • The road team has covered the run line in eight of the White Sox’s last nine games.
  • The Diamondbacks have failed to cover the run line in five of their last six games as home favorites against AL Central opponents following a win.
  • The White Sox have won the first inning in each of their last four games against opponents that held a winning record.
  • The White Sox have led after 5 innings in four of their last five games.
  • The White Sox have led after 3 innings in each of their last four day games against opponents that held a winning record.

Total Runs Facts

  • Each of the White Sox’s last six road games has gone OVER the total runs line.
  • Each of the last four games between the White Sox and Diamondbacks at Chase Field has gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last seven games between the White Sox and Diamondbacks.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last six games as road underdogs against NL West opponents.

Arizona Diamondbacks Player Prop Facts

  • Ildemaro Vargas has recorded at least one hit in each of his last 20 appearances.
  • Michael Soroka has recorded six or more strikeouts in four of his last five home appearances against AL opponents.
  • Michael Soroka has recorded a win in each of his last four appearances.
  • Ildemaro Vargas has hit at least one home run in each of the Diamondbacks’ last three games as favorites against AL Central opponents.

Chicago White Sox Player Prop Facts

  • Miguel Vargas has hit a home run in four of the White Sox’s last five games against opponents that held a winning record.
  • Andrew Benintendi has recorded at least one hit in seven of his eight previous road appearances against the Diamondbacks.

Matchup/League Facts

  • The Diamondbacks rank 1st in the league for triples this season (9).
  • The Diamondbacks rank 29th in the league for walks this season (64).
  • The White Sox rank 30th in the league for doubles this season (28).
  • The White Sox rank 28th in the league for hits this season (176).

Diamondbacks vs White Sox Prediction

I’m on the Diamondbacks in this one. I get the case to be made for the White Sox with how hot the bats have been for Chicago but I just can’t trust the White Sox bullpen in their current form. Both of these starters have been solid to this point, but I think the White Sox get the job done in the end here. Give me the Diamondbacks in this one.

Chris Ruffolo's Free Pick: Arizona Diamondbacks -156

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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