Diamondbacks vs Reds Prediction 8/22/25 MLB Picks Today

The Cincinnati Reds and the Arizona Diamondbacks meet Friday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Reds Prediction.

Starting Pitching Matchup

The Cincinnati Reds will send out Zack Littell for the start here and Littell is 9-8 with a 3.52 ERA and 103 strikeouts this season. In his career, Littell is 0-1 with a 7.99 ERA and 5 strikeouts against Arizona. The Arizona Diamondbacks will send out Ryne Nelson for the start here and Nelson is 6-3 with a 3.58 ERA and 99 strikeouts this season. This will be Nelson’s second career start against the Reds.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to rebound from a 2-1 loss at the hands of the Angels last time out to sit at 67-61 this season. After this series, the Reds will head on the road once again for a series against the Los Angeles Dodgers.

Reds Have Three-Game Win Streak Snapped

Elly De La Cruz has 135 hits with 19 home runs, 76 RBIs, 25 doubles and 31 stolen bases while TJ Friedl has 121 hits with 18 doubles, 10 home runs and 40 RBIs with 11 stolen bases. Gavin Lux has added 100 hits with 21 doubles and 48 RBIs while Spencer Steer has 15 home runs and 59 RBIs and Matt McLain has added 11 homers, 40 RBIs and 16 stolen bases as well on the year. Jose Trevino’s also chipped in 19 doubles as well this season.

Why the Cincinnati Reds will win

• The Reds have won each of their last six road games against NL West opponents that held a losing record.
• The Diamondbacks have lost five of their last six games as favorites after going to extra innings.
• The underdogs have covered the run line in each of the last eight games between the Reds and Diamondbacks.
• The Diamondbacks have failed to cover the run line in each of their last six night games against NL Central opponents following a home win.

Cincinnati Reds Player Prop Facts

• Miguel Andujar has hit a home run in three of the Reds’ last five games as underdogs against NL opponents.
• Elly De La Cruz has recorded at least one hit in each of the Reds’ last 10 Friday night games.
• Miguel Andujar has recorded a Double in each of his last three appearances in night games against teams that held a losing record.
• Elly De La Cruz ranks T6th in the league in Steals (31) this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their win over the Cleveland Guardians last time out to sit at 62-66 this season. After this series, the Diamondbacks will head on the road for a series against the Milwaukee Brewers.

Diamondbacks Win Back-To-Back Games

Corbin Carroll has 113 hits with 27 home runs, 65 RBIs, 16 triples and 22 doubles this season. Carroll also has 17 stolen bases and Geraldo Perdomo has a team-high 22 stolen bases as well as 13 home runs and 81 RBIs with a team-high 134 hits this season. Ketel Marte’s added 23 home runs and 56 RBIs as well on the year and Lourdes Gurriel has 115 hits with 23 doubles, 17 home runs and 71 RBIs.

Why the Arizona Diamondbacks will win

• The Reds have lost seven of their last eight night games against National League opponents following a road loss.
• The Diamondbacks have won each of their last five home games against NL Central opponents that held a winning record.
• The Reds have failed to cover the run line in each of their last eight night games against National League opponents following a road loss.
• The Diamondbacks have covered the run line each of their last five games against NL Central opponents that held a winning record.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit a home run in three of the Diamondbacks’ last four home games against NL opponents.
• Ryne Nelson has recorded six or more strikeouts in four of his last five appearances against opponents that held a winning record.
• Ryne Nelson has recorded a win in four of his last five home appearances against NL Central opponents.
• Ildemaro Vargas has recorded at least one hit in each of his last seven home appearances against the Reds.
• Ketel Marte ranks 4th amongst qualified players for On Base Percentage (.394) this season.

Total Runs Facts

• Each of the Diamondbacks’ last four games against NL Central opponents have gone UNDER the total runs line.
• Six of the Reds’ last seven games against NL West opponents have gone UNDER the total runs line.

Diamondbacks vs Reds Prediction

I’m on the Diamondbacks in this one. I get the case to be made for the Reds, as they’re still the only team here that’s realistically in the playoff race. However, Arizona’s still been playing some decent baseball despite the fact that they traded away a lot of assets at the trade deadline. Chase Field has had a tendency to be fairly hitter friendly, so for a pitcher like Littell, who has had major problems with giving up home runs this season, I think that could prove to be problematic here. Give me the Diamondbacks at home in this one.