Diamondbacks vs Guardians Prediction 8/18/25 MLB Picks Today

The Cleveland Guardians and the Arizona Diamondbacks meet Monday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Gavin Williams here and Williams is 7-4 with a 3.38 ERA and 127 strikeouts this season. This will be Williams’ first career start against the Diamondbacks. Arizona did not have a starting pitcher announced at the time that this article was posted.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to rebound from their 5-4 loss at the hands of the Atlanta Braves last time out to sit at 63-60 this season. After this series, the Guardians will head on the road for a series against the Texas Rangers.

Guardians Lose Three In A Row & 5 Of Last 7

Steven Kwan has 131 hits as part of a .281 batting average and 10 home runs, 22 doubles and 40 RBIs. Kyle Manzardo has 81 hits with 14 doubles, 2 triples, 21 home runs and 55 RBIs as well this year. Gabriel Arias has 20 doubles but also 113 strikeouts and Manzardo has 94 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 25 home runs and 64 RBIs with 35 stolen bases as well. Carlos Santana has also added 87 hits with 11 home runs and 51 RBIs as well this season.

Why the Cleveland Guardians will win

• The Diamondbacks have lost seven of their last eight night games against American League opponents that held a winning record.
• The road team has won each of the last four games between the Guardians and Diamondbacks.
• The Guardians have covered the run line in each of their last seven road games against National League opponents after playing the previous day.
• The Diamondbacks have failed to cover the run line in each of their last four home games against American League opponents.

Cleveland Guardians Player Prop Facts

• Lane Thomas has hit a home run in three of his last seven appearances in night games.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 10 road games against NL West opponents that held a losing record.
• Jose Ramirez has recorded at least one Double in each of the Guardians’ last four road games against NL West opponents that held a losing record.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to rebound from their 6-5 loss at the hands of the Colorado Rockies last time out to sit at 60-65 this season. After this series, the Diamondbacks will take on the Cincinnati Reds in a series at home.

Diamondbacks Drop Three In A Row

Corbin Carroll has 109 hits with 27 home runs, 64 RBIs, 14 triples and 22 doubles this season. Carroll also has 16 stolen bases and Geraldo Perdomo has a team-high 21 stolen bases as well as 13 home runs and 79 RBIs with a team-high 130 hits this season. Ketel Marte’s added 23 home runs and 56 RBIs as well on the year and Lourdes Gurriel has 111 hits with 23 doubles, 16 home runs and 66 RBIs.

Why the Arizona Diamondbacks will win

• The Guardians have lost each of their last seven Monday games against NL West opponents.
• The Diamondbacks have won five of their last six games against the Guardians.
• The Diamondbacks have covered the run line in each of their last five games against the Guardians following a loss.
• The Guardians have failed to cover the run line in six of their last seven games against teams that held a losing record.

Arizona Diamondbacks Player Prop Facts

• Zac Gallen has recorded a win in six of his last eight appearances in night games.
• Geraldo Perdomo has hit a home run in three of the Diamondbacks’ last four games against AL opponents that held a winning record.
• Geraldo Perdomo has recorded at least one hit in each of the Diamondbacks’ last eight home games.
• Zac Gallen has recorded six or more strikeouts in each of his last four home appearances.

Total Runs Facts

• Each of the Guardians’ last five road games against NL West opponents have gone UNDER the total runs line.
• Four of the Diamondbacks’ last five home games against American League opponents have gone UNDER the total runs line.

Diamondbacks vs Guardians Prediction

I’m leaning towards Cleveland here. I just don’t love this matchup for Arizona, coming off of a series in Colorado and the altitude with no day off in between to reacclimate to life below mile high. The Guardians were struggling themselves, but side-by-side, I just feel like Cleveland has the far superior bullpen and while it would be nice to know who Arizona’s starting coming into this game, I’m not sure if it matters. Give me Cleveland in this one.