Diamondbacks vs Guardians Prediction 8/20/25 MLB Picks Today

The Cleveland Guardians and the Arizona Diamondbacks meet Wednesday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Parker Messick for his major league debut here and Messick had a 5-6 record with a 3.47 ERA and 119 strikeouts in triple A this season. Brandon Pfaadt will get the start for the Diamondbacks and is 12-8 with a 5.08 ERA and 108 strikeouts this season. This will be Pfaadt’s second career start against Cleveland.

Cleveland Guardians Recap

The Cleveland Guardians will look to rebound from their 6-5 loss at the hands of the Arizona Diamondbacks on Tuesday to sit at 64-61 this season. After this series, the Guardians will head on the road for a series against the Texas Rangers.

Guardians Drop 4 Of Their Last 5

Steven Kwan has 131 hits as part of a .281 batting average and 10 home runs, 22 doubles and 40 RBIs. Kyle Manzardo has 81 hits with 14 doubles, 2 triples, 21 home runs and 55 RBIs as well this year. Gabriel Arias has 20 doubles but also 113 strikeouts and Manzardo has 94 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 25 home runs and 64 RBIs with 35 stolen bases as well. Carlos Santana has also added 87 hits with 11 home runs and 51 RBIs as well this season.

Why the Cleveland Guardians will win

• The Guardians have won five of their last six games as underdogs following a loss.
• The Diamondbacks have lost four of their last five games as favorites.
• The Guardians have covered the run line in each of their last nine road games against National League opponents after playing the previous day.
• The Diamondbacks have failed to cover the run line in each of their last six home games against American League opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has recorded at least one Double in three of the Guardians’ last four day games against NL West opponents that held a losing record.
• Jose Ramirez has hit a home run in two of the Guardians’ last three games against the Diamondbacks.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 12 road games against NL West opponents that held a losing record.
• Jose Ramirez ranks 2nd in the league in Steals (36) this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their win over the Guardians from Tuesday’s matchup to climb to 61-65 this season. After this series, the Diamondbacks will welcome the Cincinnati Reds to town for a set.

Diamondbacks Snap Three-Game Losing Streak

Corbin Carroll has 109 hits with 27 home runs, 64 RBIs, 14 triples and 22 doubles this season. Carroll also has 16 stolen bases and Geraldo Perdomo has a team-high 21 stolen bases as well as 13 home runs and 79 RBIs with a team-high 130 hits this season. Ketel Marte’s added 23 home runs and 56 RBIs as well on the year and Lourdes Gurriel has 111 hits with 23 doubles, 16 home runs and 66 RBIs.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last five day games following a win.
• The Guardians have lost each of their last five day games against National League opponents following a road loss.
• The Guardians have failed to cover the run line each of their last seven day games against teams that held a losing record.
• The Diamondbacks have covered the run line in each of their last five day games following a win.

Arizona Diamondbacks Player Prop Facts

• Brandon Pfaadt has recorded five or more strikeouts in each of his last eight appearances in day games against teams that held a winning record.
• Brandon Pfaadt has recorded a win in four of his last five appearances with the Diamondbacks as favorites against AL opponents.
• Geraldo Perdomo has hit a home run in each of the Diamondbacks’ last two day games against opponents that held a winning record.
• Lourdes Gurriel Jr. has recorded at least one hit in each of the Diamondbacks’ last 11 games as favorites.
• Corbin Carroll ranks 5th amongst qualified players for Slugging Percentage (.559) this season.

Total Runs Facts

• Six of the Guardians’ last seven road games against NL West opponents have gone UNDER the total runs line.
• Five of the Diamondbacks’ last six day games as favorites have gone UNDER the total runs line.

Diamondbacks vs Guardians Prediction

I’m on the Diamondbacks here. I just don’t know what to expect from Messick in his debut, and this is still an Arizona offense that’s been able to drum up some runs against right-handed pitching as of late. Cleveland does have the better bullpen, but I think Arizona can stake their pitching staff enough runs to get the win in this one to start the series. Give me Arizona in this one.