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Diamondbacks vs Dodgers Prediction 9/24/25 MLB Picks Today

LA Dodgers (88-69) vs. Arizona Diamondbacks (80-77)
September 24, 2025 9:40 pm EDT
The Line: Arizona Diamondbacks +128 / LA Dodgers -157; Over/Under: 8.5
(Get latest betting odds)

The Los Angeles Dodgers and the Arizona Diamondbacks meet Wednesday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Dodgers Prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Blake Snell for the start here and Snell is 5-4 with a 2.44 ERA and 67 strikeouts this season. In his last five starts against the Diamondbacks, Snell is 2-2 with a 4.50 ERA and 27 strikeouts. Ryne Nelson will get the start for the Diamondbacks and is 7-3 with a 3.34 ERA and 123 strikeouts this season. In his career, Nelson is 1-0 with a 2.12 ERA and 11 strikeouts against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to rebound from their 5-4 loss at the hands of Arizona last time out to sit at 88-69 this season. After this series, the Dodgers will take to the road for an interleague series against the Seattle Mariners.

Dodgers Drop Back-To-Back Games

Shohei Ohtani has 167 hits including 24 doubles, 53 home runs, 99 RBIs and 8 triples. Michael Conforto has 82 hits with 20 doubles while Teoscar Hernandez has 120 hits with 24 home runs, 28 doubles and 85 RBIs as well this season. Ohtani has a team-high 19 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 20 home runs and 79 RBIs as well on the year. Freddie Freeman has also logged 158 hits with a team-high 39 doubles, 21 home runs and 85 RBIs. Andy Pages also has 155 hits with 27 doubles, 25 home runs and 82 RBIs as well this season.

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last six games against the Diamondbacks following a road loss.
  • The Diamondbacks have lost five of their last six home games against the Dodgers following a win.
  • The Dodgers have covered the run line in each of their last five road games against the Diamondbacks following a road loss.
  • The Diamondbacks have failed to cover the run line in five of their last six home games against the Dodgers following a win.

Los Angeles Dodgers Player Prop Facts

  • Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.617) this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their win over the Dodgers to start the series, improving to 80-77 on the year as a result. After this set, the Diamondbacks will head to Petco Park for a division series against the San Diego Padres.

Diamondbacks Win 8 Of Their Last 11

Corbin Carroll has 143 hits with 31 home runs, 83 RBIs, 17 triples and 31 doubles this season. Carroll also has a team-high 30 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 97 RBIs with a team-high 166 hits this season. Ketel Marte’s added 26 home runs and 70 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Why the Arizona Diamondbacks will win

  • The Diamondbacks have won each of their last six games as home underdogs.
  • The Dodgers have lost five of their last six games as road favorites against National League opponents.
  • The Diamondbacks have covered the run line in each of their last 13 games as underdogs following a win.
  • The Dodgers have failed to cover the run line in seven of their last eight night games against the Diamondbacks following a loss.

Arizona Diamondbacks Player Prop Facts

  • Geraldo Perdomo ranks 5th amongst qualified players for On Base Percentage (.391) this season.

Diamondbacks vs Dodgers Prediction

I’m going to roll with Arizona in this one. I get the case to be made for the Dodgers, but the thing about Blake Snell since coming back from injury is that he’s been much stronger at home, but has been very hittable on the road. Likewise, I think that could be the case here as well. Arizona’s still playing some solid baseball right now, and I think the Diamondbacks pick up another win here. Give me Arizona.

Chris Ruffolo's Free Pick: Arizona Diamondbacks +128

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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