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Arizona Diamondbacks vs San Francisco Giants 9/25/22 MLB Picks, Predictions, Odds

San Francisco Giants (74-78) vs. Arizona Diamondbacks (71-82)
September 25, 2022 3:40 pm EDT
The Line: Arizona Diamondbacks / San Francisco Giants ; Over/Under: -
(Get latest betting odds)

The San Francisco Giants and the Arizona Diamondbacks meet in an NL West division matchup in MLB action from Chase Field on Sunday.

The San Francisco Giants will try to bounce back from a 5-2 loss at the hands of the Diamondbacks in Saturday’s matchup. Joc Pederson leads the Giants with 22 home runs and 66 RBIs while Wilmer Flores has 117 hits with 69 RBIs of his own, 27 doubles and a .234 batting average. Thairo Estrada has 121 hits with 22 doubles and 60 RBIs as well this season. Mike Yastrzemski also has 29 doubles of his own as well as a .213 batting average on the year. The Giants did not have a starting pitcher announced at the time that this article was posted.


The Arizona Diamondbacks will try to build some momentum after their win over the Giants from Saturday. Daulton Varsho’s got 120 hits, 26 home runs and 71 RBIs this season. Christian Walker has a team-high 36 home runs and 88 RBIs and Ketel Marte has 116 hits with 42 doubles while Geraldo Perdomo has 79 hits with 38 RBIs. Josh Rojas also has 108 hits with 21 doubles, 50 RBIs and a .263 batting average. Drey Jameson will start here and is 2-0 with a 1.38 ERA and 12 strikeouts this season.

San Francisco is 5-1 in their last 6 games overall and 7-1 in their last 8 road games while the under is 14-3 in their last 17 games overall. Arizona is 3-7 in their last 10 games and 1-4 in their last 5 home games while the under is 8-2 in their last 10 home games.

I get the case to be made either way in this one, but I’m looking at Arizona here. I really like what Drey Jameson’s brought to the table for the D-Backs, and while San Francisco is hot, I don’t know what San Fran’s bringing to the mound here and I don’t feel overly strong about backing the Giants in any potential bullpen game. Give me the D-Backs to build on another solid start from Jameson.  

Chris Ruffolo's Free Pick: Arizona Diamondbacks TBA

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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