Diamondbacks vs Giants Prediction 9/15/25 MLB Picks Today

The San Francisco Giants and the Arizona Diamondbacks meet Monday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Diamondbacks vs Giants Prediction.

Starting Pitching Matchup

The San Francisco Giants will start Kai-Wei Teng in this one and is 2-4 with a 7.54 ERA and 28 strikeouts this season. This will be Teng’s first career start against the Diamondbacks. Zac Gallen will get the start for the Diamondbacks here and Gallen is 11-14 with a 4.84 ERA and 157 strikeouts this season. In his last five starts against San Francisco, Gallen is 3-2 with a 3.52 ERA and 38 strikeouts.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to rebound from a 10-2 loss at the hands of the Los Angeles Dodgers last time out to sit at 75-74 this season. After this series, the Giants will head on the road for a rematch series with the Los Angeles Dodgers.

Giants Drop Back-To-Back Games

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 52 RBIs with 10 stolen bases while Heliot Ramos has 148 hits with 23 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 15 home runs and 68 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 99 hits with 21 home runs and 57 RBIs along with 20 doubles and Willy Adames has 126 hits with 20 doubles, 28 home runs and 82 RBIs of his own this season. 

Why the San Francisco Giants will win

• The underdogs have won seven of the Diamondbacks’ last eight games at Chase Field.
• The Diamondbacks have lost four of their last five games as favorites against National League opponents.
• The underdogs have covered the run line in 11 of the Diamondbacks’ last 12 games at Chase Field.
• The Diamondbacks have failed to cover the run line in 10 of their last 11 games as favorites.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in three of the Giants’ last four road games against NL West opponents.
• Willy Adames has recorded at least one hit in each of his last eight appearances with his team as an underdog against the Diamondbacks.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their 6-4 win over the Minnesota Twins last time out to sit at 75-75 this season. After this series, the Diamondbacks will take on the Philadelphia Phillies in a series at home.

Diamondbacks Looking To Pick Up Steam

Corbin Carroll has 134 hits with 30 home runs, 76 RBIs, 16 triples and 30 doubles this season. Carroll also has a team-high 28 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 95 RBIs with a team-high 157 hits this season. Ketel Marte’s added 25 home runs and 65 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last five night games at Chase Field following a win.
• The Giants have lost each of their last three games after playing the previous day.
• The Diamondbacks have covered the run line in each of their last six games following a road win.
• The Giants have failed to cover the run line in 14 of their last 16 games against National League opponents following a home loss.

Arizona Diamondbacks Player Prop Facts

• Zac Gallen has recorded five or more strikeouts in each of his nine previous appearances with the Diamondbacks as favorites against the Giants.
• Zac Gallen has recorded a win in each of his last four home appearances against the Giants.
• Corbin Carroll has hit a home run in three of the Diamondbacks’ last four home games against NL West opponents.
• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 15 games as favorites.
• Corbin Carroll has recorded a Double in three of the Diamondbacks’ last four home games against NL opponents.
• Geraldo Perdomo ranks 6th amongst qualified players for On Base Percentage (.387) this season.

Total Runs Facts

• Eight of the Giants’ last nine night games after playing the previous day have gone OVER the total runs line.
• Each of the Diamondbacks’ last four games as favorites against the Giants have gone OVER the total runs line.

Diamondbacks vs Giants Prediction

I’m on the Giants here. I get the case to be made for Arizona at home, and in fairness, Zac Gallen’s been playing some solid baseball for a lot of the last month before getting hit hard in his last start. The problem is the Giants are still hitting right-handed pitching fairly well, and side-by-side, I feel like I can trust San Francisco’s bullpen a heck of a lot more in this matchup. All in all, I think the Giants draw first blood in a really important series here, so give me the Giants.