Arizona Diamondbacks vs St. Louis Cardinals Prediction 7/18/26 MLB Picks Today

The St. Louis Cardinals and the Arizona Diamondbacks meet Saturday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The St. Louis Cardinals will start Dustin May here and May is 5-6 with a 4.55 ERA and 89 strikeouts this season. Brandon Pfaadt will start for Arizona and is 3-1 with a 4.70 ERA and 41 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their 5-4 win over Arizona last time out to sit at 51-45 this season. After this series, the Cardinals will head on the road for a set against the Angels.

Cardinals Win 3 Of Last 4

Going into Friday, Jordan Walker leads the Cardinals with 105 hits, 19 doubles, 22 home runs and 74 RBIs while Alec Burleson has 98 hits with 23 doubles, 15 home runs and 67 RBIs. JJ Wetherholt has 91 hits with 13 home runs and 36 RBIs while Ivan Herrera has 86 hits with 14 doubles, 11 home runs and 40 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 77 hits with 12 doubles and 38 RBIs and Nathan Church has 56 hits with 8 home runs and 28 RBIs this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from their loss at the hands of St. Louis last time out to sit at 49-48 this season. After this series, the Diamondbacks will take on the Athletics at home.

Diamondbacks Have Four-Game Win Streak Snapped

Entering Friday, Corbin Carroll has 87 hits including 19 doubles, 10 triples, 13 home runs and 45 RBIs. Ketel Marte has 95 hits with 19 doubles, 17 home runs and 54 RBIs and Geraldo Perdomo has 78 hits, with 13 doubles, 3 triples, 6 home runs and 34 RBIs as well this season. Nolan Arenado also has 75 hits with 17 doubles, 12 home runs and 40 RBIs and Jose Fernandez has 42 hits with 3 home runs and 15 RBIs this season. Ildemaro Vargas also has 72 hits with 13 doubles, 2 triples, 7 home runs and 47 RBIs.

St. Louis Cardinals @ Arizona Diamondbacks Betting Trends: July 18, 2026

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 3-1      ERA: 4.70
• Home Record: 1-0
• Last 5 against Cardinals: 1-0

Why the Arizona Diamondbacks will win

• The Cardinals have lost each of their last seven day games against NL West opponents following a road win.
• The Diamondbacks have won each of their last four games after playing the previous day.
• The Cardinals have failed to cover the run line in each of their last nine games against the Diamondbacks following a win.
• The Diamondbacks have covered the run line in eight of their last nine games against the Cardinals.
• The Diamondbacks have led after 3 innings in six of their last seven games as home favorites against NL Central opponents.
• The Diamondbacks have led after 5 innings in eight of their last nine home day games.
• The Diamondbacks have won the first inning in four of their last five day games against the Cardinals.

• Probable Starting Pitcher: Dustin May      Record this season: 5-6      ERA: 4.55
• Road Record: 2-3
• Last 5 against Diamondbacks: 2-2

Why the St. Louis Cardinals will win

• The underdogs have won each of the Diamondbacks’ last five games.
• The Diamondbacks have lost each of their last six day games against NL Central opponents that held a winning record.
• The Diamondbacks have failed to cover the run line in each of their last 14 Saturday day games as favorites against National League opponents.
• The Cardinals have covered the run line in seven of their last eight games as road underdogs against NL West opponents.
• The Cardinals have led after 5 innings in six of their last seven games at Chase Field against opponents that held a winning record.
• The Cardinals have won the first inning in each of their last three games.

Total Runs Facts

• Each of the Diamondbacks’ last eight day games against National League opponents have gone UNDER the total runs line.
• Each of the Cardinals’ last five day games against NL West opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Diamondbacks’ last seven games as favorites against NL Central opponents.
• There has been no run scored during the first inning in seven of the Cardinals’ last eight day games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Tim Tawa has hit a home run in three of the Diamondbacks’ last four games.
• Brandon Pfaadt has recorded four or more strikeouts in eight of his nine previous home appearances against NL Central opponents.
• Nolan Arenado has recorded at least one hit in 16 of his last 17 appearances against the Cardinals after playing the previous day.
• Brandon Pfaadt has recorded a win in each of his last three appearances.
• Corbin Carroll is one of only three players to record 10+ Home Runs and 4+ Triples this season.

St. Louis Cardinals Player Prop Facts

• JJ Wetherholt has hit a home run in two of the Cardinals’ last three road games.
• Dustin May has recorded four or more strikeouts in each of his last nine Saturday appearances.
• Masyn Winn has recorded at least one hit in each of his last 10 appearances against the Diamondbacks.
• Jordan Walker ranks T7th in the league in Hits (106) this season.

Matchup/League Facts

• The Diamondbacks rank 30th in the league for strikeouts this season (660).
• The Diamondbacks rank 2nd in the league for triples this season (22).
• The Cardinals rank 28th in the league for doubles this season (131).
• The Cardinals rank 28th in the league for strikeouts this season (723).

St. Louis Cardinals vs. Arizona Diamondbacks Prediction

I’m on the over in this game. I just don’t like the pitching matchup on either side here as I think Dustin May is one of the most hittable starters that the Cardinals have and Brandon Pfaadt has also been hittable at Chase Field this season. I think the bats come to play on Saturday, so give me the over here.