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Astros vs Angels Prediction 3/27/26 MLB Picks Today

LA Angels (1-0) vs. Houston Astros (0-1)
March 27, 2026 8:10 pm EDT
The Line: Houston Astros -163 / LA Angels 135; Over/Under: 8.5
(Get latest betting odds)

In this article we will formulate an Astros vs Angels prediction for this MLB game on Friday, March 27th at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 0-1 this season after they lost game one to the Angels by a score of 3-0 on Thursday. Houston battled for most of the game, but they allowed three late runs for the low scoring loss. The Astros recorded just three hits and they were led by Loperfido, who went 2-4 in the game. Brown allowed four hits and zero earned runs over 4.2 innings in the no decision, while Blubaugh allowed two hits and one earned run in relief for the loss. 

Last season, Houston had a 3.86 ERA with a 1.22 WHIP and a .232 opponent batting average, while they scored 686 runs with a .250 batting average and a .315 on base percentage. Christian Walker led the team with 27 home runs and 88 RBIs, while Jose Altuve added 26 home runs and 77 RBIs. The projected starting pitcher for Houston is Mike Burrows, who went 2-4 with a 3.94 ERA and a 1.24 WHIP over 96.0 innings pitched last season. 

Los Angeles Angels Betting Preview

The Los Angeles Angels are 1-0 this year after they defeated Houston by a score of 3-0 on Thursday. Los Angeles scored one run in the seventh, one in the eighth, and one in the ninth in the shutout victory. The Angels recorded nine hits in the game and they were led by Peraza, Trout, and Schanuel, who all had one RBI. Soriano allowed two hits and zero earned runs over 6.0 innings for the win, while Romano picked up the save with a scoreless ninth. 

Last season, Los Angeles had a 4.89 ERA with a 1.43 WHIP and a .260 opponent batting average, while they scored 673 runs with a .225 batting average and a .298 on base percentage. Taylor Ward (now in Baltimore) led the way with 36 home runs and 103 RBIs, while Jo Adell added 37 home runs and 98 RBIs. The projected starting pitcher for Los Angeles is Yusei Kikuchi, who went 7-11 with a 3.99 ERA and a 1.42 WHIP over 178.1 innings pitched last year. 

Why the Houston Astros will win

  • The Astros have won each of their last 10 night games against the Angels following a loss.
  • The Angels have lost each of their last 11 Friday games at Daikin Park.
  • The Angels have failed to cover the run line each of their last nine Friday games against American League opponents that held a losing record.
  • The Astros have covered the run line in 12 of their last 14 games as home favorites against the Angels following a loss.
  • The Angels have lost the first inning in six of their last seven night games against AL West opponents that held a losing record.
  • The Angels have trailed after 3 innings in each of their last six night games against AL West opponents that held a losing record.
  • The Angels have trailed after 5 innings in each of their last six night games against AL West opponents that held a losing record.

Why the Los Angeles Angels will win

  • The Astros have lost each of their last seven night games against AL West opponents following a home loss.
  • The Angels have won three of their last four games as road underdogs against the Astros.
  • The Astros have failed to cover the run line in 12 of their last 13 night games against AL West opponents following a home loss.
  • The Angels have covered the run line in nine of their last 10 night games against American League opponents following a road win.
  • The Astros have trailed after 3 innings in each of their last three games against opponents that held a winning record.
  • The Astros have trailed after 5 innings in each of their last three games against opponents that held a winning record.

Total Runs Facts

  • Seven of the last eight games between the Angels and Astros have gone UNDER the total runs line.
  • Each of the Angels’ last four games have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the last 10 games between the Angels and Astros.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Angels’ last five games at Daikin Park.

Houston Astros Player Prop Facts

  • Isaac Paredes has recorded at least one hit in each of his last eight home appearances against the Angels after playing the previous day.
  • Christian Walker has hit at least one home run in each of his last three appearances after playing the previous day.

Los Angeles Angels Player Prop Facts

  • Nolan Schanuel has recorded at least one hit in each of his 11 previous road appearances against the Astros.
  • Mike Trout has hit at least one home run in four of the Angels’ last five games.
  • Josh Lowe has recorded a Double in each of his last three appearances in night games against AL West teams that held a losing record.
  • Yusei Kikuchi has recorded six or more strikeouts in each of his last seven appearances at Daikin Park.

Astros vs Angels Prediction 

Los Angeles opened their season with a very nice shutout win on Thursday afternoon and they will look for two wins to start the year here. The Angels will start Kikuchi on the mound, who can be a solid option, but you never know what you will get with him. Houston needs more offense and they will start Burrows on the mound. Burrows is an interesting arm that only pitched 96 innings last year, but he has plenty of hype coming into this season. I was not impressed with either lineup on Thursday and I think this pitching matchup could be decent, so I will back the under here. 

David Racey's Free Pick: Under 8.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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