Astros vs Athletics Prediction 9/24/26 MLB Picks Today

In this article, we will formulate an Astros vs Athletics Prediction for this MLB matchup on Thursday, September 24^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Athletics Preview

The Athletics have a 63-95 record this season and are sitting in the 4th place of the AL West. They have a 31-46 home record and are coming off a 7-3 home win against the Angels. They will face the Rangers next.

The Athletics have a .246 batting average this season, .318 OBP and .404 Slugging percentage. Oakland’s pitching staff has a 5.43 ERA and 1.50 WHIP. Jeff McNeil is the team’s best hitter with a .265 batting average. Nick Kurtz leads the team in RBI with 69, while Shea Langeliers adds a team-high 23 home runs.

Mason Barnett (R) is the projected starting pitcher for the Athletics, and he has a 1-4 record, 7.16 ERA and 1.75 WHIP.

Houston Astros Preview

The Houston Astros have a 78-80 record this season and are sitting in the 1st place of the AL West. They have a 39-38 away record and are coming off a 5-6 road loss against the Mariners. They will face the Rangers next.

The Houston Astros have a .240 batting average this season, .314 OBP and .412 Slugging percentage. Houston’s pitching staff has a 4.50 ERA and 1.34 WHIP. Yordan Alvarez is the team’s best hitter with a .316 batting average, leading the team in RBI with 102 and adding a team-high 41 home runs.

Peter Lambert (R) is the projected starting pitcher for the Astros, and he has a 8-10 record, 3.70 ERA and 1.23 WHIP.

Houston Astros @ Athletics Betting Trends: September 24, 2026

• Probable Starting Pitcher: Mason Barnett      Record this season: 1-4      ERA: 7.16
• Home Record: 1-1
• Last 5 against Astros: 0-0

Why the Athletics will win

• The Astros have lost each of their last 12 games as favorites after going to extra innings.
• The home team has won each of the Athletics’ last nine games.
• The Astros have failed to cover the run line in each of their last 17 games as favorites after going to extra innings.
• The underdogs have covered the run line in each of the Astros’ last four games.
• The Astros have trailed after 3 innings in five of their last six games as road favorites against AL opponents.
• The Astros have lost the first inning in three of their last four games as road favorites against AL West opponents.
• The Astros have trailed after 5 innings in 14 of their last 15 games as road favorites.

• Probable Starting Pitcher: Peter Lambert      Record this season: 8-10      ERA: 3.70
• Road Record: 3-3
• Last 5 against Athletics: 1-1

Why the Houston Astros will win

• The Astros have won eight of their last nine night games against AL opponents following a loss.
• The Athletics have lost five of their last six games after playing the previous day.
• The Astros have covered the run line in each of their last eight night games against AL opponents following a loss.
• The Athletics have failed to cover the run line in 10 of their last 12 home games against AL West opponents following a win.
• The Astros have led after 3 innings in five of their last six games against AL opponents that held a losing record.
• The Athletics have trailed after 5 innings in nine of their last 10 games.

Total Runs Facts

• Each of the Athletics’ last nine night games against AL West opponents have gone OVER the total runs line.
• Eight of the Astros’ last nine games as favorites have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of Peter Lambert’s last seven road appearances as a starter.
• There has been at least one run scored in the first inning in seven of the Athletics’ last eight night games.

Athletics Player Prop Facts

• Carlos Cortes has recorded at least one hit in each of his nine previous appearances with the Athletics as underdogs against the Astros.
• Donnie Walton has hit a home run in three of the Athletics’ last five night games against opponents that held a losing record.
• Mason Barnett has recorded three or more strikeouts in four of his last five appearances with the Athletics as home underdogs.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in three of the Astros’ last four road games.
• Peter Lambert has recorded six or more strikeouts in six of his last seven appearances with the Astros as favorites against AL opponents.
• Christian Walker has recorded at least one hit in each of the Astros’ last nine road games against AL opponents that held a losing record.
• Yordan Alvarez ranks 1st amongst qualified players for Batting Average (.316) this season.

Matchup/League Facts

• The Athletics rank 30th in the league for home runs allowed this season (234).
• The Athletics rank 29th in the league for ERA this season (5.43).
• The Astros rank 30th in the league for steals this season (48).
• The Astros rank 29th in the league for walks allowed this season (638).

Astros vs Athletics Prediction

The Athletics are 3-1 in their last 4 meetings against the Astros and have won two of their last three meetings at home.

In this Astros vs Athletics Prediction, the Astros are coming as -160 road favorites. I like the Astros in this one as they are pushing to lock the NL West title. Lambert is the far better pitching option in this matchup, with a 3.17 ERA on the road, while Mason Barnett has been atrocious for the A’s, with a 7.16 ERA and 1.75 WHIP, having given up 5+ runs in three of his last four starts. On top of that, the A’s have the worst bullpen in baseball, so take the Astros to win this one on the road.