Astros vs Athletics Prediction 6/16/25 MLB Picks Today

The Houston Astros are visiting the Athletics on Monday, June 16^th at the Sutter Health Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Astros vs Athletics Prediction. We will examine:

The Athletics’ recent form and player performance

The Houston Astros’ recent form and player performance

Recent betting trends and streaks involving the Athletics

Recent betting trends and streaks involving the Houston Astros

Recent betting trends in games played between the Houston Astros vs Athletics

A summary that ties it all together and produces a favorable betting outcome for the Houston Astros vs Athletics game

Athletics Preview

The Athletics have a 29-44 record this season and are sitting in last place in the AL West. The Athletics have a 12-23 home record and are 40-28 in over/under. They are coming off a 3-2 road victory over the Royals, sweeping that series by 3-0 wins. They are playing the Guardians and the Tigers next.

The Athletics have a .254 batting average this season, a .320 OBP, and a .418 Slugging percentage. Athletics’ pitching staff has a 5.48 ERA and 1.50 WHIP. Jacob Wilson leads the Athletics with 98 hits and a team-high .367 batting average, while Tyler Soderstrom leads the team with 45 RBI, and Brent Rooker adds a team-high 15 home runs.

Mitch Spence (R) is the projected starter for the Athletics, and he has a 2-1 record, a 3.67 ERA, and a 1.20 WHIP. He has been weaker at home, with a 6.16 ERA in his 12 home games, and he looked amazing in his two starts this season, with just one earned run across 10 innings pitched. In his only previous start against the Astros last season, he gave up 2 runs in 7 innings of work.

Houston Astros Preview

The Houston Astros have a 41-30 record this season and are sitting in first place in the AL West. The Astros have a 14-17 road record and 28-40 in over/under. They are coming off a 2-1 home victory over the Twins, and are 8-2 in their last 10 games. Under is 5-2 in their last 7 games, and they are playing the Angels and the Phillies next.

The Astros have a .253 batting average this season, a .318 OBP, and a .391 slugging percentage. Houston’s pitching staff has a 3.43 ERA and 1.15 WHIP. Jeremy Pena leads the Astros with 89 hits, and he is the team’s best hitter, with a .325 batting average. Isaac Paredes leads the team in RBI with 42, adding a team-high 15 home runs.

Lance McCullers Jr. (R) is the projected starter for the Astros, and he has a 1-2 record, a 4.91 ERA, and a 1.43 WHIP. He has been unhittable on the road, having zero earned runs in 13.2 innings pitched across three road starts. He has given up 3+ runs in two of his last three starts, and in his previous start against the A’s this season, he gave up 3 runs in 6 innings of work. Lance McCullers Jr. has a record of 7-3 with an ERA of 3.32 and 98 strikeouts in 15 appearances versus the Athletics in his career.

Why the Athletics will win

• The Astros have lost eight of their last nine games as road favorites following a home win.
• The Athletics have won each of their last four games as underdogs against American League opponents following a road win.
• The Astros have failed to cover the run line in nine of their last 10 games as road favorites following a home win.
• The Athletics have covered the run line in each of their last five games.
• The Athletics have won the first inning in three of their last four games against opponents that held a winning record at Sutter Health Park.
• The Athletics have led after 3 innings in each of their last four home games.
• The Athletics have led after 5 innings in three of their last four games.

Why the Houston Astros will win

• The Athletics have lost each of their last 11 games against AL West opponents.
• The Astros have won eight of their last nine games after playing the previous day.
• The Astros have covered the run line each of their last eight night games against AL West opponents that held a losing record.
• The Athletics have failed to cover the run line each of their last six night games against American League opponents that held a winning record.
• The Astros have led after 5 innings in seven of their last eight games as road favorites against AL West opponents.
• The Astros have led after 3 innings in five of their last six night games against American League opponents that held a losing record.

Total Runs Facts

• Eight of the Astros’ last 10 road games after going to extra innings have gone UNDER the total runs line.
• Four of the Athletics’ last five home games against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last nine Monday games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Athletics’ last 10 games as home underdogs against AL West opponents.

Matchup/League Facts

• The Athletics rank 30th in the league for home runs allowed this season (104).
• The Athletics rank 29th in the league for ERA this season (5.48).
• The Astros rank 1st in the league for strikeouts this season (701).
• The Astros rank 1st in the league for opponent batting average this season (.218).

Astros vs Athletics Prediction

The Astros won both previous meetings against the A’s this season at home, with a combined 16-4 score. The A’s are 3-2 in their last 5 home meetings against the Astros, and Over is 5-1-1 in their last 7 meetings.

In this Astros vs Athletics Prediction, the Astros are coming as -160 road favorites. The Astros are rightfully favored, as they have been the superior team this season, but they have been below average on the road. Both teams have been in excellent form lately, riding lengthy winning streaks, but the A’s have the worst bullpen in the league, with the Astros the 5^th-best. McCullers has been unhittable on the road, while Spence has been terrible on the road, so I like the Astros to take care of business on the road in this one.