Astros vs Cubs Prediction 5/23/26 MLB Picks Today

In this article, we will formulate an Astros vs Cubs Prediction for this MLB matchup on Saturday, May 23^rd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 29-22 record this season and are sitting in the third place of the NL Central. They have a 18-9 home record and are coming off a 4-2 home loss by the Astros. They will face the Pirates and the Cardinals next.

The Cubs have a .240 batting average this season, .337 OBP and .394 Slugging percentage. Chicago’s pitching staff has a 4.07 ERA and 1.23 WHIP. Seiya Suzuki is the team’s best hitter with a .261 batting average. Nico Hoerner leads the team in RBI with 30, while Ian Happ adds a team-high 10 home runs.

Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 4-2 record, 4.98 ERA and 1.43 WHIP.

Houston Astros Preview

The Houston Astros have a 21-31 record this season and are sitting in the fourth place of the AL West. They have a 9-17 away record and are coming off a 4-2 road win against the Cubs. They will face the Rangers and the Brewers next.

The Astros have a .247 batting average this season, .321 OBP and .403 Slugging percentage. Houston’s pitching staff has a 5.28 ERA and 1.52 WHIP. Yordan Alvarez is the team’s best hitter with a .303 batting average, also adding a team-high 15 home runs. Christian Walker leads the team in RBI with 31.

Kai-Wei Teng (R) is the projected starting pitcher for the Astros, and he has a 2-3 record, 2.61 ERA and 1.10 WHIP.

Houston Astros @ the Chicago Cubs Betting Trends: May 23, 2026

• Probable Starting Pitcher: Colin Rea      Record this season: 4-2      ERA: 4.98
• Home Record: 2-0
• Last 5 against Astros: 2-1

Why the Chicago Cubs will win

• The Astros have lost each of their last six day games after playing the previous day.
• The Cubs have won seven of their last eight home games against teams that held a losing record.
• The Astros have failed to cover the run line in each of their last six road games against National League opponents after playing the previous day.
• The Cubs have covered the run line in four of their last five home games against the Astros.
• The Astros have trailed after 5 innings in seven of their last eight day games.
• The Cubs have led after 3 innings in five of their last six home day games.

• Probable Starting Pitcher: Kai-Wei Teng      Record this season: 2-3      ERA: 2.61
• Road Record: 0-2
• Last 5 against Cubs: –

Why the Houston Astros will win

• The Cubs have lost seven of their last eight games as favorites.
• The underdogs have won each of the Astros’ last four games at Wrigley Field.
• The Cubs have failed to cover the run line in each of their last eight day games following a loss.
• The road team has covered the run line in each of the Cubs’ last four games.
• The Astros have led after 5 innings in each of their last five day games against the Cubs.
• The Cubs have trailed after 3 innings in each of their last four games.

Total Runs Facts

• Seven of the Cubs’ last eight games against AL West opponents have gone UNDER the total runs line.
• Six of the Astros’ last seven games as underdogs against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last eight road games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight day games at Wrigley Field.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in three of the Cubs’ last four home games against opponents that held a losing record.
• Alex Bregman has recorded at least one hit in each of his last eight appearances against opponents that held a losing record.
• Pete Crow-Armstrong ranks T9th in the league in Steals (12) this season.

Houston Astros Player Prop Facts

• Christian Vazquez has hit a home run in each of his last two road appearances against the Cubs.
• Jose Altuve has recorded at least one hit in each of his last 11 appearances with the Astros as road underdogs against NL opponents.
• Yordan Alvarez ranks 3rd amongst qualified players for On Base Percentage (.416) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for walks this season (233).
• The Cubs rank 2nd in the league for on-base percentage this season (.337).
• The Astros rank 30th in the league for ERA this season (5.28).
• The Astros rank 30th in the league for walks allowed this season (254).

Astros vs Cubs Prediction

The Astros are 3-1 in their last 4 meetings against the Cubs but are 1-3 in their last 4 visits in Chicago.

In this Astros vs Cubs Prediction, the Cubs are coming as -150 home favorites. The Cubs have been struggling mightily lately with six consecutive losses and things won’t get much easier with Colin Rea on the mound, who has given up 9 runs in his last two starts. Chicago’s bats have gone ice-cold lately as they rank 29^th in baseball against right-handed pitching in the past couple of weeks so there is no way to back them here at this price. Take a stab with the Astros on the moneyline once again for plus money.