Astros vs Mariners Prediction 5/12/26 MLB Picks Today
Seattle Mariners (20-22) vs. Houston Astros (16-26)
May 12, 2026 8:10 pm EDT
The Line: Houston Astros 123 / Seattle Mariners -149; Over/Under: 8.5
(Get latest betting odds)
The Seattle Mariners and Houston Astros meet Tuesday in MLB action at Daikin Park. Here’s an Astros vs. Mariners Prediction. This article will include an Astros vs. Mariners Pick.
Seattle Mariners Betting Preview
The Seattle Mariners are 20-22 on the year and play the White Sox and Padres next. The Seattle Mariners are batting. 229 on the season, have a .317 OBP, and have a .376 slugging percentage. The Seattle Mariners’ pitching staff has a 3.71 ERA and a 1.23 WHIP. Julio Rodriguez leads the Seattle Mariners with 46 hits and 19 RBI while Cole Young and Randy Arozarena have combined for 81 hits and 35 RBI.
Bryan Woo gets the ball for the Seattle Mariners, and he is 2-2 with a 4.02 ERA and 38 strikeouts this season. Woo is 2-2 with a 2.83 ERA and 27 strikeouts in his career against the Houston Astros.
Houston Astros Betting Preview
The Houston Astros are 16-26 on the year and play the Rangers and Twins next. The Houston Astros are batting. 258 on the season, have a .333 OBP, and have a .425 slugging percentage. The Houston Astros pitching staff has a 5.50 ERA and a 1.58 WHIP. Yordan Alvarez leads the Houston Astros with 49 hits and 29 RBI while Jose Altuve and Christian Walker have combined for 80 hits and 36 RBI.
Tatsuya Imai gets the ball for the Houston Astros, and he is 1-0 with a 7.27 ERA and 13 strikeouts this season. This will be Imai’s second career game against the Seattle Mariners.
Why the Houston Astros will win
- The Mariners have lost six of their last seven games as favorites against American League opponents following a road win.
- The Astros have won four of their last five games as underdogs following a home loss.
- The Mariners have failed to cover the run line in 10 of their last 11 night games following a win.
- The Astros have covered the run line in four of their last five home games against American League opponents that held a losing record.
- The Astros have won the first inning in three of their last four home games against American League opponents that held a losing record.
- The Astros have led after 3 innings in six of their last eight home games against opponents that held a losing record.
- The Mariners have trailed after 5 innings in four of their last five games as road favorites against AL West opponents.
Why the Seattle Mariners will win
- The Mariners have won each of their last eight games against the Astros.
- The Astros have lost each of their last seven games against the Mariners following a loss.
- The Astros have failed to cover the run line in each of their last seven night games against the Mariners at Daikin Park following a home loss.
- The Mariners have covered the run line in seven of their last eight games against the Astros.
- The Mariners have won the first inning in four of their last five games against the Astros.
- The Mariners have led after 3 innings in each of their last five games at Daikin Park.
- The Astros have trailed after 5 innings in each of their last six night games at Daikin Park against AL West opponents.
Total Runs Facts
- Eight of the Astros’ last nine home games against American League opponents have gone OVER the total runs line.
- Seven of the Mariners’ last eight games after playing the previous day have gone UNDER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Mariners’ last 11 games against AL West opponents.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four games.
Houston Astros Player Prop Facts
- Isaac Paredes has recorded at least one hit in each of his last seven appearances against AL West opponents.
- Jeremy Pena has hit a home run in two of his last three appearances with the Astros as home underdogs.
- Yordan Alvarez ranks T3rd in the league in Hits (49) this season.
Seattle Mariners Player Prop Facts
- Cal Raleigh has hit a home run in three of the Mariners’ last four games against AL West opponents.
- Julio Rodriguez has recorded two or more hits in each of the Mariners’ last six night games against opponents that held a losing record.
- Randy Arozarena ranks T10th in the league in Steals (9) this season.
Matchup/League Facts
- The Astros rank T1st in the league for doubles this season (77).
- The Astros rank 30th in the league for ERA this season (5.50).
- The Mariners rank 1st in the league for walks allowed this season (102).
- The Mariners rank 28th in the league for doubles this season (54).
Astros vs Mariners Prediction
The Astros and Mariners have been quiet offensively lately and that’s due to change given the talent in both lineups. Woo has a 4.02 ERA and 1.00 WHIP on the season, but that ERA jumps to 4.50 on the road along with a .271 allowed batting average. Imai has pitched just 8.2 innings in his MLB career, but he has a 7.27 ERA and 2.08 WHIP. He’s walked 13 batters during those frames. This feels like a spot where the bats wake up and we see some offense. Give me the over in game 2 between the Astros and Mariners.