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Astros vs Mariners Prediction 5/24/25 MLB Picks Today

Seattle Mariners (29-21) vs. Houston Astros (26-25)
May 24, 2025 4:10 pm EDT
The Line: Houston Astros -122 / Seattle Mariners 102; Over/Under: 7.5
(Get latest betting odds)

In this article, we will formulate an Astros vs Mariners prediction for this MLB game on Saturday, May 24, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Betting Preview

The Seattle Mariners (29-21, 16-10 Away) are on a three-series road trip on which they swept the San Diego Padres and defeated the Chicago White Sox. Seattle bounced back from a 9-2 loss to the Houston Astros with a 5-3 victory in Game 2. Cal Raleigh led the offense with two RBI, while Emerson Hancock got the win after allowing three runs on nine hits with three strikeouts and no walks across 6.0 innings of work.

This year, the Mariners average 4.68 runs per game (9th in the MLB) on a .236/.325/.398 triple-slash. When it comes to pitching, the Mariners’ staff has a 3.72 ERA (12th) and 1.30 WHIP (19th). Cal Raleigh leads the Mariners with a .258 batting average, 17 home runs, and 35 RBI this season.

The projected starting pitcher for the Mariners is Bryan Woo, who is 5-1 in nine starts this season, with a 2.65 ERA and 0.87 WHIP in 57.2 innings.

Houston Astros Betting Preview

The Houston Astros (26-25, 16-10) split the road series with the Texas Rangers and lost to the Tampa Bay Rays before defeating the Seattle Mariners 9-2 in Game 1 of the current series. However, the M’s responded with a 5-3 victory on Friday. Isaac Paredes led the team with two RBI, while Ryan Gusto pitched for 4.1 innings in a no-decision, allowing two runs on four hits with six strikeouts and three walks.

This season, the Astros average 4.06 runs per game (22nd in the MLB) on a .250/.320/.383 triple-slash. When it comes to pitching, the Astros’ staff has a 3.48 ERA (9th) and 1.15 WHIP (3rd). Isaac Paredes leads the Astros with a .267 batting average, 11 home runs, and 31 RBI this season.

Framber Valdez will take the mound for the Astros on Saturday. The 31-year-old left-hander has a 3-4 record in ten starts this year with a 3.57 ERA and 1.13 WHIP in 63.0 innings.

Total Runs Facts

  • Eight of the Astros’ last nine day games against American League opponents have gone OVER the total runs line.
  • Seven of the Mariners’ last eight games as underdogs have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the last 10 day games between the Mariners and Astros.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Mariners’ last five games against AL West opponents.

Matchup/League Facts

  • The Astros rank 3rd in the league for hits allowed this season (357).
  • The Astros rank 4th in the league for strikeouts this season (470).
  • The Mariners rank T27th in the league for doubles this season (65).
  • The Mariners rank T27th in the league for triples this season (2).

Astros vs Mariners Prediction

The Mariners won six of the previous ten H2H encounters, including four of the last six. This season, the Mariners won three of five H2Hs. Eight of Seattle’s last ten games went Under, which was the case in seven of Houston’s previous ten games. Framber Valdez shut the Mariners out when he faced them earlier this season, and that game produced three runs with three extra innings included! Bryan Woo, on the other hand, allowed only one run in his last two games, and he hasn’t pitched for fewer than 6.0 innings this year. I expect to see a low-scoringa ffair here.

Oliver Zivic's Free Pick: Under 7.5

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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