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Astros vs Phillies Prediction 6/26/25 MLB Picks Today

Philadelphia Phillies (47-33) vs. Houston Astros (47-33)
June 26, 2025 2:10 pm EDT
The Line: Houston Astros -149 / Philadelphia Phillies 123; Over/Under: 7
(Get latest betting odds)

The Philadelphia Phillies and Houston Astros meet Thursday in MLB action at Daikin Park. Here’s a Astros vs Phillies Prediction. This article will include a Astros vs Phillies Pick.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 47-33 on the year and play the Braves, Padres, and Reds next. The Philadelphia Phillies are batting .256 on the season, have a .330 OBP, and a .402 slugging percentage. The Philadelphia Phillies pitching staff has a 3.84 ERA and a 1.27 WHIP. Trea Turner leads the Philadelphia Phillies with 96 hits and 35 RBI, while Alec Bohm and Nick Castellanos have combined for 170 hits and 77 RBI.


Cristopher Sanchez gets the ball for the Philadelphia Phillies, and he is 6-2 with a 2.87 ERA and 92 strikeouts this season. This will be Sanchez’s first career game against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 47-33 on the year and play the Cubs, Rockies, and Dodgers next. The Houston Astros are batting .256 on the season, have a .322 OBP, and a .400 slugging percentage. The Houston Astros pitching staff has a 3.43 ERA and a 1.15 WHIP. Jeremy Pena leads the Houston Astros with 101 hits and 40 RBI while Jake Meyers and Jose Altuve have combined for 156 hits and 54 RBI.

Hunter Brown gets the ball for the Houston Astros, and he is 8-3 with a 1.88 ERA and 109 strikeouts this season. This will be Brown’s second career game against the Philadelphia Phillies.

Why the Houston Astros will win

  • The Astros have won each of their last seven games at Daikin Park.
  • The Phillies have lost each of their last four road games against American League opponents.
  • The Astros have covered the run line in each of their last four day games against NL East opponents.
  • The Phillies have failed to cover the run line in each of their last five Thursday day road games against American League opponents.
  • The Astros have led after 3 innings in four of their last five day games against National League opponents.
  • The Astros have led after 5 innings in six of their last seven day games at Daikin Park against NL East opponents.

Why the Philadelphia Phillies will win

  • The Astros have lost each of their last six games as favorites against National League opponents following a home win.
  • The Phillies have won four of their last five games following a loss.
  • The Astros have failed to cover the run line in each of their last six games as favorites against National League opponents following a home win.
  • The underdogs have covered the run line in each of the Astros’ last six games at Daikin Park.
  • The Astros have trailed after 5 innings in three of their last four day games.

Houston Astros Player Prop Facts

  • Jeremy Pena has hit a home run in two of the Astros’ last three games as favorites.
  • Jeremy Pena has recorded at least one Double in each of the Astros’ last four games against NL opponents.
  • Brendan Rodgers has recorded at least one hit in each of his last 12 home appearances against NL East opponents that held a winning record.
  • Hunter Brown ranks 1st amongst qualified players for Earned Run Average (1.88) this season.

Philadelphia Phillies Player Prop Facts

  • Trea Turner has recorded a Double in four of the Phillies’ last five day games against opponents that held a winning record.
  • Max Kepler has recorded at least one hit in each of his last 10 appearances against AL West opponents that held a winning record.
  • Bryce Harper has hit at least one home run in two of his three previous appearances in day games against AL West teams that held a winning record.
  • Trea Turner ranks 4th in the league in Hits (96) this season.

Astros vs Phillies Prediction

This is going to be a must-watch game between two legit contenders and two all-star caliber pitchers. You can make a case for either side. With that said, I’m grabbing the plus money with the Phillies. The Astros have the edge at home and Brown is a legit CY Young candidate, but we’re getting plus money with Sanchez. He has a 2.87 ERA and 1.19 WHIP, and in 46 road innings, he has a 2.54 ERA and .238 allowed batting average. The Phillies have won 12 of the 15 games Sanchez has pitched this season. You can’t go wrong with the plus money. Give me the Phillies.

Randy Chambers's Free Pick: Philadelphia Phillies +123

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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