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Astros vs Red Sox Prediction 4/1/26 MLB Picks Today

Boston Red Sox (1-4) vs. Houston Astros (4-2)
April 1, 2026 2:10 pm EDT
The Line: Houston Astros 129 / Boston Red Sox -156; Over/Under: 7
(Get latest betting odds)

The Boston Red Sox and Houston Astros meet Wednesday in MLB action at Daikin Park. Here’s an Astros vs. Red Sox Prediction. This article will include an Astros vs. Red Sox Pick.

Boston Red Sox Betting Preview

The Boston Red Sox are 1-4 on the year and play the Padres and Brewers next. The Boston Red Sox are batting. 208 on the season, have a .296 OBP, and have a .333 slugging percentage. The Boston Red Sox pitching staff has a 4.78 ERA and a 1.52 WHIP. Wilyer Abreu leads the Boston Red Sox with 8 hits and 5 RBI, while Carlos Narváez and Trevor Story have combined for 8 hits and 2 RBI.

Garrett Crochet gets the ball for the Boston Red Sox, and he is 1-0 with a 0.00 ERA and 8 strikeouts this season. Crochet is 0-3 with a 6.28 ERA and 22 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 4-2 on the year and play the Athletics and Rockies next. The Houston Astros are batting. 271 on the season, have a .371 OBP, and have a .458 slugging percentage. The Houston Astros pitching staff has a 4.67 ERA and a 1.37 WHIP. Yordan Alvarez leads the Houston Astros with 8 hits and 6 RBI while Carlos Correa and Jose Altuve have combined for 14 hits and 7 RBI.

Mike Burrows gets the ball for the Houston Astros, and he is 0-1 with a 7.94 ERA and 6 strikeouts this season. This will be Burrows’ second career game against the Boston Red Sox.

Why the Houston Astros will win

  • The Red Sox have lost each of their last six road games after playing the previous day.
  • The home team has won seven of the last eight games between the Red Sox and Astros.
  • The Red Sox have failed to cover the run line in each of their last six games against AL West opponents.
  • The Astros have covered the run line each of their last six games against AL East opponents that held a losing record.
  • The Red Sox have lost the first inning in four of their last five games as road favorites against American League opponents.
  • The Astros have led after 5 innings in each of their last six games against opponents that held a losing record.
  • The Astros have led after 3 innings in five of their last six games against AL East opponents that held a losing record.

Why the Boston Red Sox will win

  • The Astros have lost each of their last five day games against AL East opponents following a win.
  • The Red Sox have won each of their last four day games against the Astros following a road loss.
  • The Red Sox have covered the run line in each of their last four day games against the Astros following a road loss.
  • The Astros have failed to cover the run line in 12 of their last 14 home games against AL East opponents that held a losing record.
  • The Astros have trailed after 5 innings in four of their last five games as underdogs.
  • The Red Sox have led after 3 innings in four of their last five day games against the Astros at Daikin Park.

Total Runs Facts

  • Each of the Red Sox’s last six day games after playing the previous day has gone UNDER the total runs line.
  • Each of the Astros’ last five games as underdogs against the Red Sox has gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last eight games as road favorites against American League opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the last 14 games between the Red Sox and Astros at Daikin Park.

Houston Astros Player Prop Facts

  • Yordan Alvarez has hit a home run in each of the Astros’ last three home games against AL East opponents.
  • Christian Walker has recorded at least one hit in each of his last 10 appearances against opponents that held a losing record.
  • Yordan Alvarez ranks T3rd in the league in Home Runs (3) this season.

Boston Red Sox Player Prop Facts

  • Wilyer Abreu has hit a home run in each of the Red Sox’s last two day games.
  • Roman Anthony has recorded at least one hit in each of his last 13 appearances in day games against teams that held a winning record.
  • Jarren Duran ranks T5th in the league in Steals (2) this season.

Matchup/League Facts

  • The Astros rank 1st in the league for runs scored this season (39).
  • The Astros rank T1st in the league for hits this season (55).
  • The Red Sox rank 27th in the league for RBIs this season (12).
  • The Red Sox rank T27th in the league for home runs allowed this season (9).

Astros vs Red Sox Prediction

The Astros’ pitching staff has been getting rocked this season and Burrows was a big part of that, allowing 9 hits and 5 runs in 5.2 innings against the Angels. Crochet is a quality pitcher who looked sharp out of the gate, but in 54 at-bats against current Astros, he’s allowing a .370 batting average, .433 on-base percentage and .952 OPS. Altuve and Alvarez especially have had success against Crochet. We’re getting a reasonable total and i see some offense in this spot. Give me the oven.

Randy Chambers's Free Pick: Over 7

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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