Astros vs Red Sox Prediction 8/13/25 MLB Picks Today

The Boston Red Sox and Houston Astros meet Wednesday in MLB action at Sutter Health Park. Here’s a Astros vs Red Sox Prediction. This article will include a Astros vs Red Sox Pick.

Boston Red Sox Betting Preview

The Boston Red Sox are 66-55 on the year and play the Marlins, Orioles, and Yankees next. The Boston Red Sox are batting .254 on the season, have a .325 OBP, and a .431 slugging percentage. The Boston Red Sox pitching staff has a 3.74 ERA and a 1.30 WHIP. Jarren Duran leads the Boston Red Sox with 126 hits and 65 RBI, while Trevor Story and Ceddanne Rafaela have combined for 219 hits and 126 RBI.

Walker Buehler gets the ball for the Boston Red Sox, and he is 7-6 with a 5.40 ERA and 75 strikeouts this season. Buehler is 1-1 with a 3.72 ERA and 16 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 67-53 on the year and play the Orioles, Tigers, and Orioles next. The Houston Astros are batting .259 on the season, have a .323 OBP, and a .408 slugging percentage. The Houston Astros pitching staff has a 3.79 ERA and a 1.20 WHIP. Jose Altuve leads the Houston Astros with 127 hits and 63 RBI while Jeremy Pena and Christian Walker have combined for 217 hits and 109 RBI.

Hunter Brown gets the ball for the Houston Astros, and he is 9-5 with a 2.51 ERA and 160 strikeouts this season. Brown is 1-0 with a 2.19 ERA and 15 strikeouts in his career against the Boston Red Sox.

Why the Houston Astros will win

• The Astros have won each of their last seven night games against AL East opponents following a loss.
• The Red Sox have lost four of their last five road games following a win.
• The Astros have covered the run line in six of their last seven night games against AL East opponents following a loss.
• The Red Sox have failed to cover the run line in four of their last five night games against AL West opponents following a road win.
• The Astros have led after 5 innings in seven of their last eight night games.
• The Astros have led after 3 innings in eight of their last 10 night games against the Red Sox at Daikin Park.

Why the Boston Red Sox will win

• The Astros have lost each of their last eight games as favorites against American League opponents.
• The Red Sox have won each of their last four games as underdogs against American League opponents.
• The Astros have failed to cover the run line in each of their last 16 games as favorites against American League opponents.
• The Red Sox have covered the run line in each of their last seven road games following a road win.
• The Astros have trailed after 5 innings in eight of their last nine games as home favorites against American League opponents.
• The Astros have lost the first inning in four of their last five home games against American League opponents.
• The Astros have trailed after 3 innings in eight of their last nine games as home favorites against American League opponents.

Houston Astros Player Prop Facts

• Yainer Diaz has hit a home run in each of the Astros’ last two games as home favorites.
• Yordan Alvarez has recorded at least one hit in each of his last 10 appearances in night games against AL teams that held a winning record.
• Jeremy Pena ranks 2nd amongst qualified players for Batting Average (.318) this season.

Boston Red Sox Player Prop Facts

• Alex Bregman has hit a home run in each of his last four road appearances against AL opponents that held a winning record.
• Jarren Duran has recorded at least one hit in each of the Red Sox’s last 12 night games.
• Trevor Story has recorded a Double in three of the Red Sox’s last four games as underdogs against AL opponents.

Astros vs Red Sox Prediction

The Red Sox are coming off a massive win yesterday, but maybe they used up all of their runs. Buehler isn’t the same pitcher he was a year or two ago, as he has a 5.40 ERA and 1.56 WHIP. In 48.1 road innings, Buehler has a 6.52 ERA and .312 allowed batting average. Brown is an all-star, and he’s allowed 12 hits and four runs in his last 17.1 innings. In 60.2 home innings, Brown has a 2.37 ERA and .174 allowed batting average. With the better pitcher on the mound and after being embarrassed, I’ll roll with the Astros.