Astros vs Reds Prediction 5/10/25 MLB Picks Today

In this article, we will formulate an Astros vs Reds prediction for this MLB game on Saturday, May 10, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Betting Preview

The Cincinnati Reds (19-21, 10-11 Away) are going through their most challenging part of the season, during which they lost six of the last seven games. After splitting the series with the Cardinals, the Reds lost to the Nationals and Braves, and opened the current series against Houston with a 3-0 defeat. Nick Martinez took the loss after allowing three runs on ten hits with five strikeouts and no walks in 6.0 innings.

This year, the Reds average 4.62 runs per game (12th in the MLB) on a .239/.320/.378 triple-slash. When it comes to pitching, the Reds’ staff has a 3.57 ERA (10th) and 1.13 WHIP (3rd). Elly De La Cruz leads the Reds with a .252 batting average, five home runs, and 25 RBI this season.

The projected starting pitcher for the Reds is Brady Singer, who is 4-2 in seven starts this season, with a 3.66 ERA and 1.14 WHIP in 39.1 innings.

Houston Astros Betting Preview

The Houston Astros (19-18, 12-7 Home) lost two series in a row to the White Sox and Brewers, but not only did they manage to avoid being swept against Milwaukee with a win in Game 3, they also opened this series against Cincinnati with a 3-0 victory. Hunter Brown got the win after allowing no runs on two hits with nine strikeouts and four walks over 5.2 innings of work.

This year, the Astros average 4.00 runs per game (19th in the MLB) on a .244/.314/.369 triple-slash. When it comes to pitching, the Astros’ staff has a 3.27 ERA (5th) and 1.12 WHIP (2nd). Yordan Alvarez leads the Astros with a .210 batting average, three home runs, and 18 RBI this season.

Lance McCullers Jr. will take the mound for the Astros on Saturday. The 31-year-old right-hander has a 0-0 record in one start this year with a 0.00 ERA and 1.64 WHIP in 3.2 innings.

Total Runs Facts

• Each of the Astros’ last five night games against National League opponents have gone UNDER the total runs line.
• Six of the Reds’ last seven road games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 17 of the Astros’ last 19 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Reds’ last seven Saturday night games against AL West opponents.

Matchup/League Facts

• The Astros rank T5th in the league for strikeouts against this season (289).
• The Astros rank 5th in the league for ERA this season (3.27).
• The Reds rank 5th in the league for steals this season (44).
• The Reds rank 5th in the league for hits allowed this season (285).

Astros vs Reds Prediction

The Reds won nine of the previous ten H2H encounters, and they were on a nine-game winning run before Houston’s win last night. I am not going to bet on the winner, but I am going with the Under because seven of the last ten H2H duels went Under. Brady Singer has been solid this year; he allowed more than three runs in a game just once, while McCullers is a top pitcher even though he was sidelined for a couple of years with an injury. I am not sure how long he will stay on the mound, but I am pretty sure that Lance will manage to keep the Reds at bay.