Athletics vs Astros Prediction 9/24/25 MLB Picks Today

The Houston Astros and Athletics meet Wednesday in MLB action at Sutter Health Park. Here’s a Athletics vs Astros Prediction. This article will include a Athletics vs Astros Pick.

Houston Astros Betting Preview

The Houston Astros are 84-73 on the year and play the Angels next. The Houston Astros are batting .250 on the season, have a .316 OBP, and a .397 slugging percentage. The Houston Astros pitching staff has a 3.87 ERA and a 1.22 WHIP. Jose Altuve leads the Houston Astros with 152 hits and 75 RBI, while Jeremy Pena and Yainer Diaz have combined for 284 hits and 130 RBI.

Hunter Brown gets the ball for the Houston Astros, and he is 12-8 with a 2.30 ERA and 201 strikeouts this season. Brown is 4-2 with a 2.54 ERA and 58 strikeouts in his career against the Athletics.

Athletics Betting Preview

The Athletics are 74-83 on the year and play the Royals next. The Athletics are batting .253 on the season, have a .318 OBP, and a .432 slugging percentage. The Athletics pitching staff has a 4.69 ERA and a 1.36 WHIP. Brent Rooker leads the Athletics with 162 hits and 87 RBI while Tyler Soderstrom and Jacob Wilson have combined for 302 hits and 151 RBI.

Luis Severino gets the ball for the Athletics, and he is 7-11 with a 4.72 ERA and 119 strikeouts this season. Severino is 3-5 with a 4.33 ERA and 71 strikeouts in his career against the Houston Astros.

Houston Astros @ Athletics Betting Trends: September 24, 2025

• Probable Starting Pitcher: Luis Severino      Record this season: 7-11      ERA: 4.72
• Home Record: 1-9
• Last 5 against Astros: 1-1

Why the Athletics will win

• The Athletics have won each of their last five games as underdogs against the Astros.
• The Astros have lost five of their last six games as road favorites against American League opponents.
• The Athletics have covered the run line each of their last seven games against teams that held a winning record.
• The Astros have failed to cover the run line in 10 of their last 11 night games against AL West opponents that held a losing record.
• The Athletics have won the first inning in each of their last four games against the Astros.
• The Athletics have led after 3 innings in five of their last six games against the Astros.
• The Athletics have led after 5 innings in each of their last six games against the Astros.

• Probable Starting Pitcher: Hunter Brown      Record this season: 12-8      ERA: 2.30
• Road Record: 7-2
• Last 5 against Athletics: 3-2

Why the Houston Astros will win

• The Astros have won 14 of their last 15 games against AL West opponents following a road loss.
• The Athletics have lost seven of their last eight games against the Astros following a home win.
• The Astros have covered the run line in each of their last eight night games against American League opponents following a road loss.
• The Athletics have failed to cover the run line in five of their last six games against the Astros following a home win.
• The Astros have led after 5 innings in each of their last eight Wednesday night games against the Athletics.
• The Astros have led after 3 innings in five of their last six road night games.

Total Runs Facts

• Seven of the Athletics’ last eight games against American League opponents have gone UNDER the total runs line.
• Seven of the Astros’ last eight road games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Athletics’ last 11 games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Astros’ last nine road games against AL West opponents.

Athletics Player Prop Facts

• Nick Kurtz has recorded at least one Double in three of his last four appearances against the Astros.
• Shea Langeliers has hit a home run in each of the Athletics’ last three games as underdogs against the Astros.
• Lawrence Butler has recorded at least one hit in each of his last nine home appearances against opponents that held a winning record.
• Luis Severino has recorded a win in four of his last five appearances with the Athletics as underdogs.
• Luis Severino has recorded five or more strikeouts in each of his last four appearances against AL West opponents.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.318) this season.

Houston Astros Player Prop Facts

• Victor Caratini has hit a home run in three of his last four appearances with the Astros as road favorites against the Athletics.
• Yordan Alvarez has recorded a Double in each of his last three road appearances against the Athletics.
• Christian Walker has recorded at least one hit in each of the Astros’ last 17 road games against opponents that held a losing record.
• Hunter Brown ranks 3rd amongst qualified players for Earned Run Average (2.30) this season.

Matchup/League Facts

• The Athletics rank T2nd in the league for doubles this season (285).
• The Athletics rank 29th in the league for home runs allowed this season (217).
• The Astros rank 1st in the league for strikeouts this season (1461).
• The Astros rank 27th in the league for steals this season (78).

Athletics vs Astros Prediction

The Astros have all but played themselves out of the AL West race, and they don’t look great right now. However, Brown has been a top-10 pitcher this season and has allowed 16 hits and 5 runs in his last 24.2 innings. Severino has been hittable all season, especially at home, where he has a 6.51 ERA and .297 allowed batting average in 76 innings. Severino does not like Sacramento, to say the least.

Also, current Astros are hitting .259 with a .311 on base percentage in 170 at bats against Severino. There are a lot of healthy numbers in that Astros lineup against a guy who spent the bulk of his career with the Yankees, facing these hitters. I like the Astros to stop the bleeding and getting a victory.