Athletics vs Cardinals Prediction 9/3/25 MLB Picks Today

In this article, we will formulate an Athletics vs Cardinals Prediction for this MLB game on Wednesday, September 3^rd at the Busch Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 69-71 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 38-33 home record and are 71-61 in over/under. They are coming off a 2-1 home victory over the A’s, that ended their two-game losing streak. Over is 7-4-1 in their last 12 games and are playing the Giants and the Mariners next.

The Cardinals have a .247 batting average this season, .315 OBP and .383 Slugging percentage. St. Louis’ pitching staff has a 4.27 ERA and 1.31 WHIP. Alec Burleson leads the Cardinals with 123 hits, and he is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 74, adding a team-high 20 home runs.

Matthew Liberatore (L) is the projected starting pitcher for the Cardinals, and he has a 6-11 record, 4.32 ERA and 1.32 WHIP.

Athletics Preview

The Athletics have a 64-76 record this season and are sitting on the last place of the AL West. The Athletics have a 35-36 road record and are 71-63 in over/under. They are coming off a 1-2 road defeat by the Cardinals, and are 1-4 in their last 5 games. Over is 6-3 in their last 9 games and are playing the Red Sox and the Angels next.

The Athletics have a .253 batting average this season, .319 OBP and .433 Slugging percentage. Athletics’ pitching staff has a 4.80 ERA and 1.37 WHIP. Brent Rooker leads the Athletics with 146 hits, while Jacob Wilson is the team’s best hitter with a .315 batting average. Tyler Soderstrom adds a team-high 81 RBI, while Shea Langeliers adds a team-high 29 home runs.

Jeffrey Springs (L) is the projected starter for the Athletics, and he has a 10-9 record, 4.17 ERA, and 1.19 WHIP.

Why the St. Louis Cardinals will win

• The Athletics have lost four of their last five games.
  The Cardinals have won each of their last three night games after playing the previous day.
  The Athletics have failed to cover the run line in four of their last five games.
  The Cardinals have covered the run line in four of their last five games as favorites against American League opponents.
  The Cardinals have led after 3 innings in six of their last seven games as favorites against American League opponents.
  The Cardinals have led after 5 innings in four of their last five games as favorites against American League opponents.

Why the Athletics will win

• The Athletics have won each of their last six games as road underdogs following a loss.
  The Cardinals have lost each of their last eight Wednesday games as favorites.
  The Cardinals have failed to cover the run line in each of their last 12 games as favorites following a home win.
  The Athletics have covered the run line in each of their last eight road games following a loss.
  The Cardinals have trailed after 5 innings in each of their last eight night games at Busch Stadium against American League opponents.
  The Cardinals have lost the first inning in 10 of their last 12 night games against American League opponents.
  The Athletics have led after 3 innings in each of their last five night games against opponents that held a losing record.

Total Runs Facts

• Nine of the Cardinals’ last 10 games as favorites against AL West opponents have gone OVER the total runs line.
  Six of the Athletics’ last seven games as underdogs have gone OVER the total runs line.
  The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Athletics’ last 10 games as underdogs against National League opponents.
  The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four games between the Athletics and Cardinals.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (6).
  The Cardinals rank 29th in the league for strikeouts this season (1031).
  The Athletics rank 2nd in the league for doubles this season (259).
  The Athletics rank 29th in the league for home runs allowed this season (197).

Athletics vs Cardinals Prediction

The Cardinals are 5-3 in their last 8 head-to-head meetings against the Athletics, and both teams are tied 3-3 wins in their last 6 meetings in St. Louis. Under is 5-2 in their last 7 meetings.

In this Athletics vs Cardinals Prediction, the Cardinals are coming as -115 home favorites. I don’t trust either pitcher in this matchup, but looking at their home/away splits, Springs has been better on the road, with a 3.66 road ERA, and Liberatore weaker at home, with a 4.55 home ERA. Liberatore has 3+ earned runs in his last four starts, so I will side with the road team and the Athletics in this one.